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9-Phenylacridine

9-Phenylacridine structure

CAS No:
602-56-2
Formula:
C19H13N
Chemical Name:
9-Phenylacridine
Synonyms:
Acridine,9-phenyl-;9-Phenylacridine;NSC 62730;9PA
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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9-Phenylacridine Basic Attributes

Molecular Weight：

255.32

Exact Mass：

255.31

EC Number：

210-020-3

NSC Number：

62730

HScode：

2933990090

Characteristics

PSA：

12.9

XLogP3：

5.2

Density：

1.181 g/cm3

Melting Point：

184 °C

Boiling Point：

404 °C

Flash Point：

179.8ºC

Refractive Index：

1.711

Safety Information

safety instructions：

S22-S24/25

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P304+P340, P305+P351+P338, P312, P330, P337+P313, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 92 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

9-phenyl acridine

9-Phenylacridine Use and Manufacturing

Methods of Manufacturing

In a 250 mL three-necked flask, 21.4 g (0.1 mol) of 9-chloroacridine, 14.6 g (0.12 mol) of phenylboronic acid, 0.11 g of Pd (PPh3) 4 catalyst, 100 g of toluene, 2 g of sodium carbonate, and 18 g of deionized water were sequentially added. , Heated to 40 C., reacted for 3 hours, cooled to 25 C., removed the solvent by rotary evaporation, washed with 100 g of methanol and dispersed, and filtered to obtain a crude product. The crude product was purified with 80 g of toluene and dried to obtain 24.7 g of the product, a yield of 96.8%. HPLC The content is 99.65%.A mixture of dimethyl phthalate (20 mmol), diphenylamine (10 mmol), benzoic acid( 10 mmol) and zinc chloride (20 mmol) was stirred and microwave irradiated at 100 C and 120 W for 2 h. The mixture was diluted with dichloromethane, washed with water, diluted with sodium hydroxide, washed again with water and dried over magnesium sulphate. After evaporationof the solvent, the crude product was recrystallised from toluene/ethanol. Yield 65%; the % of elements found/calculated, C 89.42/89.38, H 5.10/5.13, N 5.48/5.49; 1H NMR (CDCl3), delta, ppm (J, Hz): 7.21 (1H, m); 7.39 (2H, m); 7.42 (2H, m); 7.57 (2H, m); 7.69 (2H, dd, J = 11.8); 7.74 (2H, m), 8.28 (2H, dd, J = 11.8).

Manufacturing Info：

Acridine, 9-phenyl-: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:255.3
XLogP3:5.2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:255.104799419
Monoisotopic Mass:255.104799419
Topological Polar Surface Area:12.9
Heavy Atom Count:20
Complexity:298
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 9-Phenylacridine

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

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9-Phenylacridine 99% powder 602-56-2 Dideu

CAS No.: 602-56-2

Grade: Chemical Grade

Content: 99%

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