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4-Piperidineethanol

4-Piperidineethanol structure

CAS No:
622-26-4
Formula:
C7H15NO
Chemical Name:
4-Piperidineethanol
Synonyms:
4-Piperidineethanol;4-(2-Hydroxyethyl)piperidine;2-(Piperidin-4-yl)-1-ethanol;NSC 93818;2-(Piperidin-4-yl)ethanol;2-(4-Piperidyl)ethanol
Categories:
Pharmaceutical Intermediates > Cardiovascular Agents

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Description

white crystalline low melting solid

4-Piperidineethanol Basic Attributes

Molecular Weight：

129.2

Exact Mass：

129.20

EC Number：

210-727-7

NSC Number：

93818

DSSTox ID：

DTXSID8060749

HScode：

2933399090

Characteristics

PSA：

32.3

XLogP3：

0.2

Appearance：

White solid. Practically odorless

Density：

0.9±0.1 g/cm3

Melting Point：

132.5 °C

Boiling Point：

227.5 °C

Flash Point：

>230 °F

Refractive Index：

1.454

Storage Conditions：

Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-37/39-24/25

Marks：

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (90.16%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 61 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

4-Piperidineethanol Use and Manufacturing

Methods of Manufacturing

(0.06 mol) of lithium tetrahydride was added to anhydrous tetrahydrofuran (80 mL) under a nitrogen atmosphere under ice-cooling, and 4.95 g (0.03 mol) of pulverized 4-piperidine acetic acid was slowly added to the reaction solution , In which the reaction temperature was controlled to be less than 30 ° C. The reaction was allowed to proceed at 25 ° C overnight. The temperature was lowered to 0 ° C, and 3 mL of water, 3 mL of 30percent aqueous sodium hydroxide and 3 mL of water were gradually added dropwise. The mixture was stirred at 25 ° C for 30 min. The solvent was evaporated under reduced pressure to give 2.23 g (62.5percent) of a light yellow solid.

Uses

4-Piperidineethanol have been used as a intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK

Manufacturing Info：

4-Piperidineethanol: INACTIVE

Computed Properties

Molecular Weight:129.20
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:129.115364102
Monoisotopic Mass:129.115364102
Topological Polar Surface Area:32.3
Heavy Atom Count:9
Complexity:69.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-Piperidineethanol

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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4-Piperidineethanol

CAS No.: 622-26-4

Content: 99.00%

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