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β-Amyrin

β-Amyrin structure

β-Amyrin 

structure
  • CAS No:

    559-70-6

  • Formula:

    C30H50O

  • Chemical Name:

    β-Amyrin

  • Synonyms:

    Olean-12-en-3-ol,(3β)-;Olean-12-en-3β-ol;(3β)-Olean-12-en-3-ol;β-Amyrenol;β-Amyrin;β-Amyrine;3β-Hydroxyolean-12-ene;(+)-β-Amyrin;β-Amirin;NSC 527971

  • Categories:

    Natural Products  >  Terpenes

Description

β-Amyrin, an ingredient of the surface wax of tomato fruit and dandelion coffee, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD[1].


Beta-amyrin is a pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants. It has a role as a plant metabolite and an Aspergillus metabolite. It is a pentacyclic triterpenoid and a secondary alcohol. It derives from a hydride of an oleanane.

β-Amyrin Basic Attributes

426.72

426.72

209-204-6

KM8353IPSO

Characteristics

20.2

11.06

1.0±0.1 g/cm3

197 °C

bp0.8 260°

217.7±20.7 °C

1.539

D19 +99.8° (c = 1.3 in benzene)

Safety Information

NONH for all modes of transport

3

22

22-45

Xi

P264, P270, P301+P312, P330, P501

H302

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

beta-amyrin

β-Amyrin Use and Manufacturing

Uses

nociceptive

Lipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> C30 isoprenoids (triterpenes) [PR0106]

Computed Properties

Molecular Weight:426.7
XLogP3:9.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:426.386166214
Monoisotopic Mass:426.386166214
Topological Polar Surface Area:20.2
Heavy Atom Count:31
Complexity:790
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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