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tert-Butyllithium

tert-Butyllithium structure

CAS No:
594-19-4
Formula:
C4H9Li
Chemical Name:
tert-Butyllithium
Synonyms:
Lithium,(1,1-dimethylethyl)-;Lithium,tert-butyl-;(1,1-Dimethylethyl)lithium;tert-Butyllithium;t-Butyllithium;tBuLi;101638-96-4
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

tert-Butyllithium is a colorless crystalline solid or colourless to pale yellow solution. It is more reactive than n- or sec-butyllithium and has similar properties. However, it is thermally stable. Dixon and co-workers have heated tert-Butyllithium to 100°C for 20 hr with little decomposition.

tert-Butyllithium Basic Attributes

Molecular Weight：

64.06

Exact Mass：

64.08640

EC Number：

209-831-5

HScode：

29319090

Characteristics

PSA：

XLogP3：

1.75410

Appearance：

slightly cloudy liquid

Density：

0.862-0.966 g/cm³

Boiling Point：

36-40 °C

Flash Point：

20 °F

Storage Conditions：

2-8°C

Vapor Density：

~3 (vs air)

Flammability characteristics：

Its heptane solution spontaneously ignites in the air; it is flammable when exposed to heat; spontaneously reacts with water

Safety Information

Packing level：

Hazard category：

4.3

Transport codes：

UN 3394 4.2/PG 1

wgk germany：

hazard class code：

11-15-17-34-51/53-65-66-67-50/53-38-14/15

safety instructions：

26-36/37/39-43-45-62-61-16-33-9

Marks：

F,C,N

Storage features：

Warehouse ventilated at low temperature and dry; waterproof, anti-open flame

Precautionary statement(s)：

P210-P222-P223-P231 + P232-P370 + P378-P422

Hazard Statements：

H225-H250-H260-H304-H314-H336-H411

GHS Classification：

|Danger|H250 (100%): Catches fire spontaneously if exposed to air [Danger Pyrophoric liquids; Pyrophoric solids]|P210, P222, P223, P231+P232, P260, P264, P280, P301+P330+P331, P302+P334, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P335+P334, P363, P370+P378, P402+P404, P405, P422, and P501|Aggregated GHS information provided by 71 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

n-BuLi

tert-Butyllithium Use and Manufacturing

Uses

There are no commercial uses of t-butyllithium, but it is used as a polymerization initiator and as a metalating agent in the laboratory.

Alkylating and metalating agent. Reagent for the introduction of the tert-butyl group.

tert-Butyllithium (t-BuLi) is the most reactive of the commercially available organolithium reagents. It is supplied as a standard solution in hydrocarbon solvents, usually in a bottle sealed with a septum.

Manufacturing Info：

Lithium, (1,1-dimethylethyl)-: ACTIVE

Computed Properties

Molecular Weight:64.1
Hydrogen Bond Acceptor Count:1
Exact Mass:64.08642872
Monoisotopic Mass:64.08642872
Heavy Atom Count:5
Complexity:8.4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of tert-Butyllithium

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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tert-Butyllithium

CAS No.: 594-19-4

Content: 99.00%

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

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Tertiary butyl lithium CAS 594-19-4

CAS No.: 594-19-4

Grade: Pharmaceutical Grade

Content: 99%

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