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2-Acetamidophenol

2-Acetamidophenol structure

CAS No:
614-80-2
Formula:
C8H9NO2
Chemical Name:
2-Acetamidophenol
Synonyms:
Acetamide,N-(2-hydroxyphenyl)-;Acetanilide,2′-hydroxy-;Acetanilide,o-hydroxy-;N-(2-Hydroxyphenyl)acetamide;2′-Hydroxyacetanilide;o-Acetamidophenol;2-Acetamidophenol;N-Acetyl-o-aminophenol;2-(Acetylamino)phenol;o-(Acetylamino)phenol;2-Acetaminophenol;o-Hydroxyacetanilide;o-Acetaminophenol;N-Acetyl-2-aminophenol;2-(N-Acetylamino)phenol;2-Hydroxyacetanilide;NSC 3989;Orthocetamol;89332-63-8
Categories:
Chemical Reagents > Organic Reagents

Description

Paracetamol (4-acetamidophenol). 2-Acetamidophenol is a promising analgesic and an anti-arthritic agent[1].

2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.

2-Acetamidophenol Basic Attributes

Molecular Weight：

151.16

Exact Mass：

151.16

BRN：

607592

EC Number：

210-396-9

UNII：

4AS8989RNI

NSC Number：

3989

DSSTox ID：

DTXSID8022082

HScode：

29242995

Characteristics

PSA：

49.3

XLogP3：

0.7

Appearance：

Off-white to beige to brown Powder

Density：

1.3±0.1 g/cm3

Melting Point：

208 °C

Boiling Point：

343.1ºC at 760 mmHg

Flash Point：

161.3±23.2 °C

Refractive Index：

1.619

Water Solubility：

0.01 M

Storage Conditions：

Store below +30°C.

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

2811

wgk germany：

hazard class code：

36/38-22-36/37/38

safety instructions：

26-36-37/39

RTECS Number：

AE4025000

Marks：

Xi,Xn

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (97.92%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 48 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2-hydroxyacetanilide

2-Acetamidophenol Use and Manufacturing

Methods of Manufacturing

Mix ortho-aminophenol, acetic acid and acetic anhydride (that is, crystals appear), then directly heat to dissolve on fire, stop heating, cool, dilute with water, precipitate crystals and filter to dry, recrystallize with ethanol at 70-80℃ And get the finished product.

Uses

An Acetaminophen (A161220) impurity.

Manufacturing Info：

Acetamide, N-(2-hydroxyphenyl)-: ACTIVE

Computed Properties

Molecular Weight:151.16
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:151.063328530
Monoisotopic Mass:151.063328530
Topological Polar Surface Area:49.3
Heavy Atom Count:11
Complexity:147
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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