1,4-Benzenediamine, 2-methyl-, hydrochloride (1:2)

195.09000

194.03800

GY506235UT

DTXSID4060650

Solid

2921519090

52.04000

3.92580

34-36 °C(lit.)

170-173°C 31mm

>230 °F

Miscible with water (est)

4.12X10-12 mm Hg at 25 deg C (est)

Henry's Law constant = 6.38X10-18 atm-cu m/mol at 25 °C (est)

When heated to decomposition it emits very toxic fumes of NOx and HCl

XT0350000

P261, P264, P270, P271, P272, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, P501

H301

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Evidence is given supporting testing of the class of compounds phenylenediamines for their toxic effects on human health and the environment. The results of toxicity testing of 22 compounds are tabulated as are the effects for which testing is being considered for 13 compounds, and the uses or potential uses of 47 phenylenediamines.[UNITED STATES EPA; PHENYLENEDIAMINES; RESPONSE TO INTERAGENCY TESTING COMMITTEE; FED REGIST 47(5) 973 (1982)]

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

A 1-mL subcutaneous administration of 0.4% aqueous (14)C-toluene-2,5-diamine hydrochloride (specific activity: 12.8 mCi/g toluene-2,5-diamine) was given to 18 Sprague-Dawley rats. More than 65% of the radioactivity was excreted in the urine within 24 hours. After 5 days, approximately 15% of the radioactivity was found in the feces, and 6.9% was detected in the total-body homogenate.|Eighteen Sprague-Dawley rats were given 1-mL oral doses of a 1.6% aqueous solution of radioactive toluene-2,5-diamine hydrochloride (specific activity, 15.8 mCi/g toluene-2,5-diamine) by stomach tube. Within 24 hours, more than 70% of the radioactivity was excreted in the urine. After 5 days, a total of 10% was detected in the feces, 1.2% was detected in the body homogenate, and 1.4% remained in the gastrointestinal tract.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

2,5-diaminotoluene

1,4-Benzenediamine, 2-methyl-, hydrochloride (1:2): INACTIVE

Thin-layer chromatography has been used to separate and identify aromatic amines (Bassl A et al; Thin-Layer Chromatography of Primary Aromatic Amines; J Prakt Chem 36: 265 (1967))... Hair Dyes Have Been Analyzed for Aromatic Amines, including 2,5-Diaminotoluene, by Extraction with Methanol, Separation by Thin Layer Chromatography and Visualization with para-Dimethylaminobenzaldehyde (Legatowa B; Determination of Aromatic Amines and Aminophenols in Hair Dyes; Rocz Panstw Zakl Hig 24: 393 (1973)). ... Gas chromatography has been used to determine isomeric diaminotoluenes (Boufford CE; Determination of Isomeric Diaminotoluenes by Direct Gas Liquid Chromatography; J Gas Chromat 6: 438 (1968))... /Aromatic amines/