beta-Boswellic acid
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beta-Boswellic acid
structure -
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CAS No:
631-69-6
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Formula:
C30H48O3
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Chemical Name:
beta-Boswellic acid
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Synonyms:
Urs-12-en-23-oic acid,3-hydroxy-,(3α,4β)-;Urs-12-en-24-oic acid,3α-hydroxy-;β-Boswellic acid;(3α,4β)-3-Hydroxyurs-12-en-23-oic acid;3α-Hydroxyurs-12-en-24-oic acid;beta-Boswellic acid;1285527-37-8
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CAS No:
Description
β-Boswellic acid is isolated from the gum resin of Boswellia serrate.β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation[1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells[2].
Solid
Boswellia also called Indian Frankincense is an extract of the gummy oleoresin derived from beneath the bark of the Boswellia serrata tree, which is native to India, the Middle East and Northern Africa. The resin is rich in triterpenic acids and has been used for centuries in traditional Ayurvedic medicine to treat inflammatory conditions. More recently, Boswellia serrata extracts have been marketed as helpful in arthritis, colitis and asthma. Extracts of Boswellia serrata have not been linked to serum aminotransferase elevations during treatment or to instances of clinically apparent acute liver injury.
Characteristics
57.53000
9.38
Solid
1.1±0.1 g/cm3
238 °C
556.0±50.0 °C at 760 mmHg
304.1±26.6 °C
1.555
0.001876 mg/L @ 25 °C (est)
-20°C Freezer
D +107° (c = 0.75 in CHCl3)
Toxicity
Boswellia serrata extract has not been linked to serum enzyme elevations during therapy, although there have been few prospective studies in humans that have reported on its effects on laboratory test results in any detail. In small trials, Boswellia extracts have appeared to be well tolerated with only minor and few adverse effects which have been similar in frequency among persons receiving placebo. Despite wide scale use as an herbal supplement, Boswellia extract has not been convincingly linked to published instances of clinically apparent liver injury. Boswellia is often included in multi-ingredient dietary supplements some of which have been implicated in liver injury, but a specific contribution from Boswellia to the injury could not be established. The frequency of hypersensitivity reactions to Boswellia is also not known.
Drug Information
Boswellia also called Indian Frankincense is an extract of the gummy oleoresin derived from beneath the bark of the Boswellia serrata tree, which is native to India, the Middle East and Northern Africa. The resin is rich in triterpenic acids and has been used for centuries in traditional Ayurvedic medicine to treat inflammatory conditions. More recently, Boswellia serrata extracts have been marketed as helpful in arthritis, colitis and asthma. Extracts of Boswellia serrata have not been linked to serum aminotransferase elevations during treatment or to instances of clinically apparent acute liver injury.
Herbal and Dietary Supplements
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)
beta-boswellic acid
beta-Boswellic acid Use and Manufacturing
The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
Lipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> C30 isoprenoids (triterpenes) [PR0106]
Computed Properties
Molecular Weight:456.7
XLogP3:8.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:456.36034539
Monoisotopic Mass:456.36034539
Topological Polar Surface Area:57.5
Heavy Atom Count:33
Complexity:878
Defined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Active compound in frankincense with anti-inflammatory and potential anti-cancer properties, traditionally used for joint and respiratory health
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