1,2-Dichlorobutane

127.01

127.01

1731376

210-469-5

93880

DTXSID8027244

0

2.24260

1.1116 g/cm³ @ Temp: 25 °C

-70.34°C (estimate)

124.1 °C

80 °F

n20/D 1.445(lit.)

Insoluble in water; soluble in ether, chloroform and carbon tetrachloride.

28 mm Hg ( 32 °C)

4.38 (AIR= 1)

2.25-9.25%, 20°F

VAPOR PRESSURE: 1 MM HG @ -23.6 °C

527 °F (275 °C)

III

3

UN 1993 3/PG 3

3

10-36/37/38

9-16-23-26-33-36/37/39

Xi

P261-P305 + P351 + P338

H226-H315-H319-H335

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 46 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Stabilization: Treatment is largely supportive. Watch for respiratory depression & arrhythmias. Obtain arterial blood gases. Administer oxygen if there is evidence of altered mental status or dyspnea. Treat hypotension with volume expansion & vasopression. Use lidocaine or beta-blockers for ventricular arrhythmias. Skin: Remove contaminated clothing. Wash affected area with soap & copious amounts or water. Eye: Irrigate the eye for 15-20 min. Obtain a consultation if symptoms persist. Oral: Most of the halogenated solvents ingested in quantities of 1-2 swallows may be partially removed by ipecac-induced emesis if admin within a few hr to a patient who has not lost the gag reflex, is not seizing, is not markedly lethargic, or is not in coma. Observe the patient in the upright position to lessen the possibility of aspiration. Activated charcoal is probably ineffective. Inhalation: Move from the contaminated area. Provide a source of oxygen & prepare for mechanical ventilation. If the patient is unconscious & the pulse is absent, initiate CPR measures. Enhancement of Elimination: Maintain good ventilation. Hemodialysis or hemoperfusion are not likely to be useful because of the high lipophilic properties of these solvents. Antidote: N-acetylcysteine may restore depleted glutathione stores, but no adequate clinical studies are available to validate this possible treatment. Supportive Care: Watch for cardiac dysrhythmias, aspiration pneumonitis, hepatotoxicity, & hypoxic encephalopathy. Monitor for arrhythmia for at least 24 hr & for hepatorenal failure for about 3 days. Obtain a chest x-ray, arterial blood gas, EKG, serum creatinine, & hepatic aminotransferase. Check electrolyte imbalance daily. Treat renal failure with dialysis & hepatic failure with fresh frozen plasma, vitamin K, a low-protein diet, neomycin, & lactulose. Watch fluid & electrolyte balance. /Halogenated hydrocarbons/

Symptomatology: 1A) Inhalation, high vapor concn: gasping, refusal to breathe, coughing, substernal pain, & extreme respiratory distress at vapor concn over 1500 ppm. Irritation of eyes & upper respiratory mucosa appears promptly after exposure to concentrated vapors. Lacrimation & headache are prominent. Coma may occur rapidly. B) Inhalation, low vapor concn: central nervous depression & moderate irritation of respiratory system. Headache is frequent. 2) Dermal: severe skin irritation with marked inflammatory response of epidermis & underlying tissues. 3) Oral: acute gastrointestinal distress with pulmonary congestion & edema. Central nervous depression, perhaps even in the absence of impaired oxygen uptake. 4) By any route, possible late injuries to liver, kidneys & heart. 5) After inhalation exposures, malaise, headache, chest & abdominal discomfort & irritability have been reported to persist for several weeks & perhaps for several years.

Butane, 1,2-dichloro-: ACTIVE

OVER THE PAST 8 YR, RESEARCH HAD BEEN CONDUCTED ON DEVELOPING THE ANALYTICAL CAPABILITY TO COLLECT, CHARACTERIZE & QUANTIFY VOLATILE ORGANIC COMPOUNDS PRESENT IN TYPICAL AMBIENT AIR ENVIRONMENTS. THE OVERALL PROGRESS MADE ON THIS DEVELOPMENT WAS SUMMARIZED. THE DESCRIBED ANALYSIS SYSTEM ENCOMPASSED THE COLLECTION & CONCN OF ORGANIC POLLUTANTS FROM AMBIENT AIR, INCLUDING 1,2-DICHLOROBUTANE, USING TUBES PACKED WITH POLYMERIC BEADS. AFTER SAMPLING, THE CARTRIDGES WERE THERMALLY HEATED UNDER A HELIUM FLOW, THE COMPOUNDS DESORBED, CRYOFOCUSED & INTRODUCED INTO A HIGH-RESOLUTION GLASS OR FUSED CAPILLARY FOR CHARACTERIZATION & MEASUREMENT BY GAS CHROMATOGRAPHY/MASS SPECTROMETRY/COMPUTER TECHNIQUES.