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Diphemanil methyl sulfate

Diphemanil methyl sulfate structure

CAS No:
62-97-5
Formula:
C20H24N.CH3O4S
Chemical Name:
Diphemanil methyl sulfate
Synonyms:
Piperidinium,4-(diphenylmethylene)-1,1-dimethyl-,methyl sulfate (1:1);Piperidinium,4-(diphenylmethylene)-1,1-dimethyl-,methyl sulfate;4-(Diphenylmethylene)-1,1-dimethylpiperidinium methyl sulfate;Demotil;N,N-Dimethyl-4-piperidylidene-1,1-diphenylmethane methylsulfate;Diphemanil;Diphenatil;Diphenmanil methylsulfate;Diphenmethanil;Diphenmethanil methylsulfate;Nivelona;Prantal;Vagophemanil;Vagophemanil methyl sulfate;Diphemanil methyl sulfate;Diphemanil methosulfate;Nivelon;Prantil;Prentol;Talpran;Variton;Diphemanil metilsulfate;NSC 41725;Biphemanil
Categories:
Biochemical Engineering > Inhibitors

Description

Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.IC50 value: Target: mAChRDiphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smo

Diphemanil methylsulfate is the alkene resulting from the formal Wittig olefination of benzophenone and 1,1-dimethyl-4-bromopiperidinium methylsulfate. A quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids, saliva and sweat, It is used topically in the treatment of hyperhidorsis (excessive sweating). It has a role as a muscarinic antagonist, a parasympatholytic and a bronchodilator agent. It is a quaternary ammonium salt and a member of piperidines.

Diphemanil methyl sulfate Basic Attributes

Molecular Weight：

389.51

Exact Mass：

389.16600

EC Number：

200-552-4

UNII：

W2ZG23MGYI

NSC Number：

41725

DSSTox ID：

DTXSID9022948

Characteristics

PSA：

74.8

XLogP3：

4.49130

Melting Point：

194.5 °C

Toxicity：

LD50 in rats, mice, guinea pigs (mg/kg): 1107, 64, 404 orally (Margolin)

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

hazard class code：

6.1

Precautionary statement(s)：

P260, P264, P270, P271, P280, P284, P301+P310, P301+P312, P304+P340, P305+P351+P338, P310, P320, P321, P330, P403+P233, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (83.33%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P271, P280, P284, P301+P310, P301+P312, P304+P340, P305+P351+P338, P310, P320, P321, P330, P403+P233, P405, and P501|Aggregated GHS information provided by 12 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

MeSH Entry Terms：

diphemanil methylsulfate

Diphemanil methyl sulfate Use and Manufacturing

Uses

Bronchodilatator;Anticholinergic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:389.5
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:389.16607952
Monoisotopic Mass:389.16607952
Topological Polar Surface Area:74.8
Heavy Atom Count:27
Complexity:426
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Diphemanil mesylate

CAS No.: 62-97-5

Content: 99.00%

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Guide of Diphemanil methyl sulfate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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Diphemanil methyl sulfate

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