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Chlortetracycline hydrochloride

Chlortetracycline hydrochloride structure

CAS No:
64-72-2
Formula:
C22H23ClN2O8.ClH
Chemical Name:
Chlortetracycline hydrochloride
Synonyms:
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,hydrochloride (1:1),(4S,4aS,5aS,6S,12aS)-;2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride;2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride,[4S-(4α,4aα,5aα,6β,12aα)]-;2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride,(4S,4aS,5aS,6S,12aS)-;Aureomycin monohydrochloride;Chlortetracycline hydrochloride;Chlortetracyclinium chloride;Aureocycline;Aureomycin hydrochloride;Biomycin hydrochloride;7-Chlorotetracycline hydrochloride;7-Chlorotetracycline monohydrochloride;Aurofac 100;Aureovit 12C80;Isphamycin;Aureociclina;Fermycin Soluble;NSC 13252;1087726-23-5
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Chlortetracycline Hydrochloride is a specific and potent calcium ionophore antibiotic, inhibit binding of aminoacyl-tRNA to ribosomes.

Chlortetracycline Hydrochloride is a tetracycline with broad-spectrum antibacterial and antiprotozoal activity. Chlortetracycline hydrochloride is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. This tetracycline is active against a wide range of gram-positive and gram-negative organisms, spirochetes, rickettsial species, certain protozoa and Mycoplasma and Chlamydia organisms.|A TETRACYCLINE with a 7-chloro substitution.

Chlortetracycline hydrochloride Basic Attributes

Molecular Weight：

515.34

Exact Mass：

514.090942

EC Number：

200-591-7

UNII：

O1GX33ON8R

NSC Number：

756691|13252

DSSTox ID：

DTXSID2045076

NCI Thesaurus Code：

C47448

HScode：

29413020

Characteristics

PSA：

182

XLogP3：

1.94130

Appearance：

faint yellow to yellow Powder

Melting Point：

210-215 °C (dec.)(lit.)

Boiling Point：

694.1°C at 760 mmHg

Water Solubility：

soluble in water;1 M NaOH: soluble 50mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 orally in rats: 10300 mg/kg (Goldenthal)

Specific rotation：

D23 -240°

Collision Cross Section：

197.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

Hazard category：

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

QI7800000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (94.5%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 109 companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)|Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

MeSH Entry Terms：

4-Epimer Chlortetracycline

Chlortetracycline hydrochloride Use and Manufacturing

Uses

An antimicrobial and antibacterial.This compound contains an undetermined amount of epi-chlortetracycline It is a broad-spectrum antibiotic and has antibacterial effects on both Gram-positive and Gram-negative bacteria. Cell-permeable fluorescent probes are used to measure the endoplasmic reticulum Ca2+ flow.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:515.3
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:514.0909711
Monoisotopic Mass:514.0909711
Topological Polar Surface Area:182
Heavy Atom Count:34
Complexity:1010
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Hydrochloric acid

Starch

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Guide of Chlortetracycline hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
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Chlortetracycline hydrochloride

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