Pyridoxine

Pyridoxine is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

Solid

Pyridoxine is a hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid. It has a role as a cofactor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a monohydroxypyridine, a vitamin B6, a member of methylpyridines and a hydroxymethylpyridine.|Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. While many plants and microorganisms are able to synthesize pyridoxine through endogenous biological processes, animals must obtain it through their diet. More specifically, pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. It's important to note that Vitamin B6 is the collective term for a group of three related compounds, pyridoxine, pyridoxal, and pyridoxamine, and their phosphorylated derivatives, pyridoxine 5'-phosphate, pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate. Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA). Pyridoxine is used medically for the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy (due to [DB00951]'s mechanism of action which competitively inhibits the action of pyridoxine in the above-mentioned metabolic functions). It is also used in combination with [DB00366] (as the commercially available product Diclectin) for the treatment of nausea and vomiting in pregnancy.|Pyridoxine is a Vitamin B6 Analog. The chemical classification of pyridoxine is Vitamin B 6, and Analogs/Derivatives.|The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

500 ml with stirring, 150 ml of tetrahydrofuran was added to the three-necked flask of the thermometer and the condenser.25.3g (0.1mol)Ethyl 2-methyl-3-hydroxypyridine-4, 5-dicarboxylate, 9.49 g (0.25 mol) of sodium borohydride, Then, 7.5 g (0.125 mol) of glacial acetic acid was slowly added dropwise with stirring, and when glacial acetic acid was added dropwise, Control the temperature of the melt solution system to 30 ° C, After the completion of the dropwise addition, slowly heat up to 60 ° C, Reflux reaction 3 hours;After the reaction is completed, the solution system is cooled to 5 ° C, and 20percent dilute hydrochloric acid solution is added to the solution system.The pH of the solution system is adjusted to 2, and 20percent sodium hydroxide is added dropwise to the solution system.Adjust the pH to 14, when adding dilute hydrochloric acid and sodium hydroxide to the solution system, Control the temperature of the solution system below 10 ° C to prevent the addition of hydrochloric acid solution, The temperature in the solution system is too high; the system is filtered again, and the filter residue is washed twice with tetrahydrofuran.The washings and the filtrate were combined, and tetrahydrofuran was distilled off, and 150 ml of ethyl acetate was added to the residue, and the mixture was extracted three times.The extract phases were combined, and then ethyl acetate was evaporated under reduced pressure, and then 20 ml of anhydrous ethanol was added to the residue after concentration.And pass hydrogen chloride gas to saturation, then stand at room temperature for 3 hours, filter, After washing and drying, 19.3 g of vitamin B6 having a purity of 98.8percent was obtained, and the yield of vitamin B6 of the present example was 94percent

A form of vitamin B6It is a vitamin itself and can be used as a food additive. It can also be used as an intermediate of pyrithione hydrochloride. It can regulate the vitality of sebaceous glands, and can be used in cleansing and care products for facial oil control. Can also be used in hair care products to improve oily hair and healthy hair follicles.

Molecular Weight:169.18
XLogP3:-0.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:169.07389321
Monoisotopic Mass:169.07389321
Topological Polar Surface Area:73.6
Heavy Atom Count:12
Complexity:142
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes