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1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1)

1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1) structure

CAS No:
636-00-0
Formula:
C8H11NO3.BrH
Chemical Name:
1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1)
Synonyms:
1,2,4-Benzenetriol,5-(2-aminoethyl)-,hydrobromide (1:1);1,2,4-Benzenetriol,5-(2-aminoethyl)-,hydrobromide;6-Hydroxydopamine hydrobromide;6-Hydroxydopamine hydrogen bromide;2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

Oxidopamine hydrobromide is a selective catecholaminergic neurotoxin, depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. In vitro: Oxidopamine hydrobromide-induced apoptosis of PC12 cells was initiated by superoxide generation followed by caspase cascade activation, which was associated with the suppressed Akt phosphorylation and increased p38 phosphorylation. It is likely that pCPT-cAMP prevented the Oxidopamine hydrobromi

A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.

1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1) Basic Attributes

Molecular Weight：

250.09

Exact Mass：

249.000046

EC Number：

211-247-0

UNII：

TWC1D4W0WB

NSC Number：

238469

DSSTox ID：

DTXSID30212972

HScode：

2922299090

Characteristics

PSA：

86.71000

XLogP3：

1.96300

Appearance：

tan to brown solid

Melting Point：

216-220 °C(lit.)

Boiling Point：

406ºC at 760 mmHg

Flash Point：

199.3ºC

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

DC4600000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

MeSH Entry Terms：

6 Hydroxydopamine

1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1) Use and Manufacturing

Biochemical reagents can induce Parkinson~"s disease rat model.

Computed Properties

Molecular Weight:250.09
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:249.00006
Monoisotopic Mass:249.00006
Topological Polar Surface Area:86.7
Heavy Atom Count:13
Complexity:142
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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6-HYDROXYDOPAMINE HYDROBROMIDE

CAS No.: 636-00-0

Content: 99.00%

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Guide of 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1)

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1)

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