Phenylphosphine

110.09

110.09

211-325-4

856X9KP929

1424

511703

2924

DTXSID7073224

Clear, colorless liquid

2902909090

0

1.49 /Estimated/

colorless liquid

1.00 g/cm³

148-151 °C

160.5 °C

-20°F

1.578

Insoluble in water.

-20°C

760 mmHg ( 160 °C)

3.79 (vs air)

Inhalation-rat LC50: 38 ppm/4 hours

Spontaneously flammable in air; toxic phosphorus oxide fumes are released in the fire

Foul odor

Henry's Law constant = 2.38X10-4 atm-cu m/mol @ 25 °C /Estimated/

Spontaneously combustible in high concentrations in air. Potential exposure to gaseous phenylphosphine when polyphosphinates are heated above 200 °C|Hydroxyl radical reaction rate constant = 1.95X10-12 cu cm/molec-sec @ 25 °C /Estimated/

Pyrophoric in air. Insoluble in water. Slowly generates flammable or noxious gases in contact with water.

Amines, Phosphines, and Pyridines

Strong Reducing Agent

PHENYL PHOSPHINE is a reducing agent. They slowly generate flammable or noxious gases in contact with water. Phosphides react quickly upon contact with moisture or acids to give the very toxic gas phosphine; phosphides also can react vigorously with oxidizing materials. In general, materials in this group are incompatible with oxidizers such as atmospheric oxygen. They are violently incompatible with acids, particularly oxidizing acids.

Combustible Liquid

I

4.2

2924

3

11-17-23/24/25-36/37/38-48/20-51/53-62-65-67-38-20/21/22

16-26-36/37/39-45-62-61-36/37

SZ2100000

F;T;N,N,T,F,Xn

Storeroom low temperature, ventilated, dry; container closed; fireproof; stored separately from oxidants, food ingredients

Spontaneously combustible in high concentrations in air. Potential exposure to gaseous PF when polyphosphinates are heated above 200ºC.

P210-P222-P231-P261-P273-P422

H225-H250-H302-H304-H315-H319-H336-H361f-H373-H411

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Spontaneously combustible in high concentrations in air. Potential exposure to gaseous PF when polyphosphinates are heated above 392F.

Flash point data are not available for this chemical, but it is probably combustible. (NTP, 1992)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H250 (100%): Catches fire spontaneously if exposed to air [Danger Pyrophoric liquids; Pyrophoric solids]|P210, P222, P261, P264, P270, P271, P280, P301+P310, P302+P334, P302+P352, P304+P340, P305+P351+P338, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P405, P422, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P201, P202, P210, P260, P261, P264, P270, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should wash daily at the end of each work shift. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|(See protection codes)

High concentration of the substance may ignite spontaneously on contact with air.|It is pyrophoric in air.

Fire fighters should wear complete protective clothing including self-contained breathing apparatus. /Use/ foam, dry powder.

Evacuate danger area! Consult an expert! Chemical protection suit including self-contained breathing apparatus. Remove all ignition sources. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|The worker should wash daily at the end of each work shift.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.

The substance is irritating to the respiratory tract, the eyes and the skin.

Recommended Exposure Limit: Ceiling Value: 0.05 ppm (0.25 mg/cu m).

Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Remove all ignition sources. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Fireproof. Well closed. Keep in a well-ventilated room.

Exposure above the OEL could cause death. The substance is irritating to the respiratory tract, eyes and skin.

NO open flames.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection.

most toxic

LC50 Rat (male) inhalation 38 ppm/4 hr (175 mg/cu m) (95% confidence interval: 31-47 ppm)

The substance can be absorbed into the body by inhalation.

Exposure Routes: inhalation, ingestion, skin and/or eye contact Target Organs: Blood, central nervous system, skin, reproductive system (NIOSH, 2016)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Refer for medical attention.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . /Phosphine and Related Compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Phosphine and Related Compounds/|Maintain open airway and assist ventilation if necessary. Administer supplemental oxygen, and treat noncardiogenic pulmonary edema if it occurs. treat seizures and hypotension if they occur. Patients with a history of of significant phosphine inhalation or phosphine ingestion should be admitted and observed for 48 to 72 hours for delayed onset of pulmonary edema. Intravenous magnesium has been used to treat cardiac arrhythmias otherwise unresponsive to treatment. In severe poisoning adrenal function may be compromised and intravenous hydrocortisone should be considered, especially if hypotension dose not respond to iv fluids and vasopressors.

/SIGNS AND SYMPTOMS/ Symptoms of phosphine intoxication in the adults /after an accidental exposure aboard a ship/ included shortness of breath, cough, and pulmonary irritation, nausea, headache, jaundice, and fatigue. The highest concentrations of phosphine (20-30 ppm) were measured in a void space on the main deck near the air intake for the ship's ventilation system. In some of the living quarters, /phosphine/ levels of 0.5 ppm were detected. /Phosphine/

The substance can be absorbed into the body by inhalation.|inhalation, ingestion, skin and/or eye contact

In Animals: blood changes, anemia, testicular degeneration; loss of appetite, diarrhea, lacrimation (discharge of tears), hind leg tremor; dermatitis

Cough. Shortness of breath. Sore throat.

Redness. Pain.

Redness. Pain.

Blood, central nervous system, skin, reproductive system