Enantholactam
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Enantholactam
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CAS No:
673-66-5
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Formula:
C7H13NO
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Chemical Name:
Enantholactam
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Synonyms:
2(1H)-Azocinone,hexahydro-;Hexahydro-2(1H)-azocinone;Heptanoic acid,7-amino-,lactam;ω-Enantholactam;ζ-Enantholactam;Enantholactam;Oenantholactam;7-Aminoheptanoic acid lactam;Octahydroazocin-2-one;7-Heptanelactam;1-Aza-2-cyclooctanone;Perhydro-2-azocinone;2-Oxoheptamethyleneimine;ω-Heptanolactam;3,4,5,6,7,8-Hexahydro-2(1H)-azocinone;NSC 77088;Azocan-2-one;ω-Heptalactam
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CAS No:
Characteristics
29.1
0.2
WHITE TO BROWN CRYSTALLINE POWDER
0.9±0.1 g/cm3
35-38 °C
148-150 °C
>230 °F
1.445
Safety Information
NONH for all modes of transport
3
22
24/25
CN4810000
Xn
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.
Enantholactam Use and Manufacturing
It is obtained by oximation and rearrangement of cycloheptanone. Sulfuric acid and hydroxylamine sulfate are pumped into a dry reaction pot, heated and stirred to dissolve, and cycloheptanone is slowly added at 110-120°C. After adding, keep stirring for 1.5h, and cool to 70-80℃. Discharge into crushed ice while hot, add sodium hydroxide solution to pH 14. It was extracted with chloroform, and the extract was distilled to recover the chloroform and then distilled under reduced pressure. The fraction at 140°C (2.0kPa) was collected to obtain enantolactam.
This product is an intermediate of the drug guanethidine.
Computed Properties
Molecular Weight:127.18
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:127.099714038
Monoisotopic Mass:127.099714038
Topological Polar Surface Area:29.1
Heavy Atom Count:9
Complexity:101
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
