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Methylmagnesium chloride

Methylmagnesium chloride structure

Methylmagnesium chloride 

structure
  • CAS No:

    676-58-4

  • Formula:

    CH3ClMg

  • Chemical Name:

    Methylmagnesium chloride

  • Synonyms:

    Magnesium,chloromethyl-;Methylmagnesium chloride;Chloromethylmagnesium

  • Categories:

    Organic Chemistry  >  Organometallic Compounds

Description

dark brown solution


Liquid


Methylmagnesium chloride is an alkylmagnesium halide and a one-carbon compound.

Methylmagnesium chloride Basic Attributes

74.79250

73.97740

211-629-7

DTXSID7052365

29319090

Characteristics

0

1.27330

Liquid

1.013

66ºC

-17ºC

Solubility in water: reaction

Flammables + water-Freezer (-20ºC)e area

DANGEROUS ... EXPLOSION RISK.

Moisture sensitive|... May react violently with water. /Methyl magnesium bromide in ethyl ether/

Safety Information

I

4.3

UN 3399

1

R11; R15; R19; R34

S16-S29-S33-S36/37/39-S45-S7/8

F; C

P210-P231+232-P280-P370 + P378-P402 + P404-P403 + P235

H225-H260-H302-H314-H335-H351

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Danger|H225 (64.43%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P222, P223, P231+P232, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P334, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P335+P334, P363, P370+P378, P402+P404, P403+P235, P405, P422, and P501|Aggregated GHS information provided by 149 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

...DANGEROUS FIRE...RISK.

...DANGEROUS ... EXPLOSION RISK.

/GUIDE 138: SUBSTANCES - WATER-REACTIVE (EMITTING FLAMMABLE GASES)/ Fire or Explosion: Produce flammable gases on contact with water. May ignite on contact with water or moist air. Some react vigorously or explosively on contact with water. May be ignited by heat, sparks or flames. May re-ignite after fire is extinguished. Some are transported in highly flammable liquids. Runoff may create fire or explosion hazard. /Organometallic substance, liquid, water-reactive, flammable/|/GUIDE 138: SUBSTANCES - WATER-REACTIVE (EMITTING FLAMMABLE GASES)/ Health: Inhalation or contact with vapors, substance, or decomposition products may cause severe injury or death. May produce corrosive solutions on contact with water. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution. /Organometallic substance, liquid, water-reactive, flammable/|/GUIDE 138: SUBSTANCES - WATER-REACTIVE (EMITTING FLAMMABLE GASES)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meter (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate the area before entry. /Organometallic substance, liquid, water-reactive, flammable/|/GUIDE 138: SUBSTANCES - WATER-REACTIVE (EMITTING FLAMMABLE GASES)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Organometallic substance, liquid, water-reactive, flammable/|For more DOT Emergency Guidelines (Complete) data for METHYLMAGNESIUM CHLORIDE (8 total), please visit the HSDB record page.

Drug Information

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/|Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Magnesium and Related Compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Magnesium and Related Compounds/

Methylmagnesium chloride Use and Manufacturing

Methods of Manufacturing

REACTION OF METHYL CHLORIDE AND MAGNESIUM IN ANHYDROUS DIETHYL ETHER, USUALLY IN THE PRESENCE OF AN INITIATOR

Uses

Methyl magnesium chloride is a very widely used Grignard reagent widely used in drug synthesis such as quinolone antibiotics.


Intermediates

Production

(1977) AT LEAST 4.58X10+7 GRAMS|(1981) PROBABLY GREATER THAN 2.27X10+6 GRAMS

AVAILABLE AS A SOLN IN TETRAHYDROFURAN.

All other basic organic chemical manufacturing|Magnesium, chloromethyl-: ACTIVE

Computed Properties

Molecular Weight:74.79
Hydrogen Bond Acceptor Count:2
Exact Mass:73.9773695
Monoisotopic Mass:73.9773695
Heavy Atom Count:3
Complexity:4.8
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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