 Home > Encyclopedia > 1-METHYL-1,2,4-TRIAZOLE

1-METHYL-1,2,4-TRIAZOLE

1-METHYL-1,2,4-TRIAZOLE structure

CAS No:
6086-21-1
Formula:
C3H5N3
Chemical Name:
1-METHYL-1,2,4-TRIAZOLE
Synonyms:
1-Methyltriazole;1-METHYL-1,2,4-TRIAZOLE;1-METHYL-1H-1,2,4-TRIAZOLE;1H-1,2,4-Triazole, 1-methyl-;1-Methyl-1,2,4-triazole, 99%, 99%
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Request for Quotation

Description

1-METHYL-1,2,4-TRIAZOLE is Pale-Yellow Liquid

1-METHYL-1,2,4-TRIAZOLE Basic Attributes

Molecular Weight：

83.094

Exact Mass：

83.048347

DSSTox ID：

DTXSID20209699

HScode：

2933990090

Characteristics

PSA：

30.7

XLogP3：

Appearance：

plae-yellow liquid

Density：

1.2±0.1 g/cm3

Melting Point：

16°C

Boiling Point：

175.3ºC at 760 mmHg

Flash Point：

59.8±22.6 °C

Refractive Index：

1.582

Safety Information

hazard class code：

R36/37/38

safety instructions：

S26-S36/37/39

Marks：

Xi: Irritant;F: Flammable;

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

1-methyl-1H-1,2,4-triazole

1-METHYL-1,2,4-TRIAZOLE Use and Manufacturing

Methods of Manufacturing

50 mmol of sodium methoxide was added to a mixture of 50 mmol of 1, 2, 4-triazole (a compound of the formula II) and 50 ml of a methanol solution, and the resulting suspension was stirred at 25 ° C for 30 min. Thereafter, 60 mmol of methyl bromide was added dropwise, and the mixture was refluxed at 70 ° C for 12 h. The volatiles in the reaction mixture were removed in vacuo, washed with chloroform, and solid impurities were filtered, after, rotary evaporation removal and the washing solvent, a colorless liquid of 1-methyl-1, 2, 4-triazole 3.90 g was obtained.

Uses

1-METHYL-1,2,4-TRIAZOLE is an azole compound used for binding affinity with various cytochrome P 450 (CYP) proteins

Computed Properties

Molecular Weight:83.09
Hydrogen Bond Acceptor Count:2
Exact Mass:83.048347172
Monoisotopic Mass:83.048347172
Topological Polar Surface Area:30.7
Heavy Atom Count:6
Complexity:45.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 1-METHYL-1,2,4-TRIAZOLE

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

1-Methyl-1H-1,2,4-triazole

CAS No.: 6086-21-1

Content: 99.00%

Inquiry