Sodium Calcium Aluminosilicate, Hydrated

318.300408

181.89

215-685-3

TSCA listed

92.2

2.42[at 20℃]

73mg/L at 25℃

Separate from air, water, halocarbons, alcohols. Store in a cool, dry, well-ventilated location. Outside or detached storage is preferred. Inside storage should be in a standard flammable liquid storage warehouse, room, or cabinet. /Aluminum alkyls/

...Violently explosive when they come into contact with water. /Aluminum alkyls/

Less sensitive than trialkylaminums to oxidation upon exposure to air. /Alkylaluminum halides/

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

H315

Aluminum compounds are treated under anhydrous conditions to prevent violent reactions, recover solvent, and form Al compounds suitable for landfill by reaction with anhydrous hydrolysis agent, eg calcium hydroxide. /Aluminum compounds/|SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Extremely reactive with air, moisture, and compounds containing active hydrogen... /Alkyl aluminum compounds/|Reacts violently with a broad range of materials including air & water. /Aluminum alkyls/

Hydrated sodium calcium aluminosilicate used as an anticaking agent in food for human consumption is generally recognized as safe when used at a level not exceeding 2% in accordance with good manufacturing practice.|Hydrated sodium calcium aluminosilicate used as an anticaking agent in animal drugs, feeds, and related products is generally recognized as safe when used at a level not exceeding 2% in accordance with good manufacturing or feeding practice.

Not Classified

Wear appropriate personal protective clothing to prevent skin contact. /Aluminum (soluble salts and alkyls, as Al/|Wear appropriate eye protection to prevent eye contact. /Aluminum (soluble salts and alkyls, as Al)/|Protective clothing and a high standard of training in the necessary precautionary measures are essential for the handling of the materials. /Aluminum alkyls/

Certain polymerization catalysts, such as aluminum alkyls, react & burn violently on contact with water. /Aluminum alkyls/|Aluminum alkyls are organic aluminum compounds that are highly reactive and dangerous because of spontaneous burning in air. /Aluminum alkyls/|Prophoric material in flammable solvent. Vapors are heavier than air & may travel to a source of ignition & flash back. /Aluminum alkyls/

...Violently explosive when they come into contact with water. /Aluminum alkyls/

Stop flow of liquid before extinguishing fire. Use dry chemical or carbon dioxide. DO NOT use water as straight stream directly on spilled material. Water fog can be used to control fire. DO NOT use halogenated extinguishing agents on spilled material. Violent reaction may result. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance. /Aluminum Alkyls/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Work clothing that becomes wet or significantly contaminated should be removed and replaced. /Aluminum (soluble salts and alkyls, as Al)/|Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. /Aluminum (soluble salts and alkyls, as Al)/|The worker should immediately wash the skin when it becomes contaminated. /Aluminum (soluble salts and alkyls, as Al)/|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

Irritation of the eyes has been noted in patients who have been exposed /to aluminum alkyls/. /Aluminum alkyls/|May cause minor irritation to lungs or eyes. /Aluminum (dust or powder)/

Recommended Exposure Limit: 10-Hr Time-Weighted Avg: 10 mg/cu m (total). /Aluminum/|Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 mg/cu m (resp). /Aluminum/|Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 2 mg/cu m. /Aluminum (soluble salts and alkyls, as Al)/|Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 mg/cu m. /Aluminum (pyro powders and welding fumes, as Al)/

Adding 0.5% hydrated sodium calcium aluminosilicate to diets formulated with aflatoxin contaminated corn reduced the detrimental effects of the mycotoxin on live weight gains and feed intake. Hepatocellular changes normally associated with aflatoxin consumption could not be detected histopathologically in liver sections from pigs fed contaminated diets plus the aluminosilicate sorbent.|Previous research has demonstrated that hydrated sodium calcium aluminosilicate (HSCAS, or NovaSilÑ) tightly binds and immobilizes aflatoxins in the gastrointestinal tract of animals. This action markedly reduces the bioavailability and toxicity of these food and feedborne poisons. Since AfB1 is a potent developmental toxin in rats, /the/ objectives in this study were to evaluate the ability of HSCAS and a common zeolite (clinoptilolite) to protect the developing fetus. Aluminosilicates, HSCAS 1, HSCAS 2, and cliniptilolite, were added to the diet at a level of 0.5% (w/w) and administered to Sprague-Dawley rats throughout pregnancy. Test animals were dosed orally with AfB1 at 2 mg/kg bw dissolved in corn oil during gestation days 6-13, and dams and /fetuses/ were evaluated for various maternal, developmental and histological parameters on day 20. Clays, by themselves, were not toxic; AfB1 alone resulted in 75% maternal mortality, 98% embryonic resorptions and typical liver and kidney lesions. Animals treated with HSCAS 1 and HSCAS 2 (plus AfB1) were comparable to controls. /Hydrated sodium calcium aluminosilicate/

/OTHER TOXICITY INFORMATION/ ...In one study, individual particles from the lungs of 75 randomly selected autopsy cases were analyzed using an automated scanning electron microscopy /energy dispersive X-ray microanalysis system. An average of 613 million particles, of exogenous origin, per gram of dry lung tissue were found, the major classes of particles being silica, talc, aluminum silicates, and rutile. In the second study, lungs from 50 randomly selected autopsy cases were analyzed using gravimetric and X-ray diffraction analysis. The median total particulate material was 0.33 g, for cases in which samples were prepared by high temperature ashing, and 0.41 grams, for those in which nitric acid digestion was used. The median amount of quartz for all cases, was 0.044 g. Samples of eighteen of the 75 lungs previously analyzed by automated scanning electron microscopy were also analyzed using gravimetric and X-ray diffraction analysis. ... /Aluminum Silicates/

HSCAS

Miscellaneous manufacturing|Silicic acid, aluminum calcium sodium salt: ACTIVE