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Calcium folinate

Calcium folinate structure

CAS No:
1492-18-8
Formula:
C20H23N7O7.Ca
Chemical Name:
Calcium folinate
Synonyms:
L-Glutamic acid,N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-,calcium salt (1:1);Glutamic acid,N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-,calcium salt (1:1),L-;Calcium L-folinate;Calcium leucovorin;Calcium folinate;Calcium 5-formyltetrahydrofolate;Lederfoline;Leucovorin calcium;Leucovorin calcium salt;Folinic acid calcium salt;Rescuvolin;NSC 3590;Wellcovorin;Folidan;Folinate-SF calcium;6035-86-5;6209-45-6;30771-29-0;1236362-90-5
Categories:
Active Pharmaceutical Ingredients > Vitamins and Minerals Medicines

Description

Leucovorin Calcium is a reduced folic acid.IC50 Value: 30 μM for zcSHMT and70 μM for zmSHMT [2]Target: Antifolatein vitro: Increasing concentrations of leucovorin (N5-CHO-THF) inhibit both zcSHMT and hcSHMT activities substantially, yet to a lesser extent than zmSHMT. The IC50 of leucovorin is approximately 30 μM for zcSHMT and higher than 70 μM for zmSHMT. The differential inhibition is evident with the presence of 10 μM leucovorin, the concentration estimated in serum in a high-dose le

Calcium folinate is a tetrahydrofolic acid.|The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

Calcium folinate Basic Attributes

Molecular Weight：

511.5

Exact Mass：

511.112823

EC Number：

216-082-8

DSSTox ID：

DTXSID3036999|DTXSID3045564|DTXSID20872448

ATC Code：

V - Various

HScode：

2942000000

Characteristics

PSA：

221

Appearance：

powder

Melting Point：

240-250ºC

Water Solubility：

DMSO « 1 (mg/mL)

Specific rotation：

(c = 1, H2O) [a]20 D = 13.0 ± 2º

Collision Cross Section：

198.8 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|202.35 Å² [M-H]- [CCS Type: DT, Method: stepped-field]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-42/43

safety instructions：

26-36-36/37-22-45

RTECS Number：

MA0600500

Marks：

Stability/Shelf Life：

Bulk: Calcium leucovorin was stable in bulk form after 4 weeks storage at 60 ° C (HPLC). Solution: Leucovorin in 0.1 N NaOH (pH 13) and in deionized water (pH6) was stable at room temperature under laboratory illumination for at least 24 hours (HPLC).

Precautionary statement(s)：

P261-P280-P305 + P351 + P338-P342 + P311

Hazard Statements：

H315-H317-H319-H334-H335

GHS Classification：

|Danger|H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 52 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Drug Indication：

MeSH：

Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)|A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)

MeSH Entry Terms：

5 Formyltetrahydrofolate

Calcium folinate Use and Manufacturing

Uses

antianemic, antidote to folic acid antagonists 1. It is mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.). 2. It is used to prevent severe toxic effects caused by methotrexate overdose or high-dose treatment. 3. Megaloblastic anemia caused by folic acid deficiency. 4. When combined with fluorouracil, it is used to treat advanced colon cancer and rectal cancer. It is used to relieve the toxic reaction caused by the overdose of aminopterin and methotrexate, and can also be used to treat giant red blood cell anemia.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:511.5
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:7
Exact Mass:511.1128369
Monoisotopic Mass:511.1128369
Topological Polar Surface Area:221
Heavy Atom Count:35
Complexity:900
Defined Atom Stereocenter Count:1
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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