Rimantadine hydrochloride
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Rimantadine hydrochloride
structure -
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CAS No:
1501-84-4
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Formula:
C12H21N.ClH
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Chemical Name:
Rimantadine hydrochloride
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Synonyms:
Tricyclo[3.3.1.13,7]decane-1-methanamine,α-methyl-,hydrochloride (1:1);1-Adamantanemethylamine,α-methyl-,hydrochloride;Tricyclo[3.3.1.13,7]decane-1-methanamine,α-methyl-,hydrochloride;EXP 126;α-Methyl-1-adamantanemethylamine hydrochloride;Rimantadine hydrochloride;1-(1-Aminoethyl)adamantane hydrochloride;Remantadine;Meradan;Meradane;JP 61;Remantadin;Flumadine;Roflual;NSC 206764;1-(1-Adamantyl)ethylamine hydrochloride;1-(Adamantan-1-yl)ethan-1-amine hydrochloride;12710-47-3;33122-80-4
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Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs
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CAS No:
Description
White Crystalline SolidRimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile.
Rimantadine hydrochloride is an organic molecular entity.|An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
Rimantadine hydrochloride Basic Attributes
215.76
215.144073
1806241-263-5
759149|206764
DTXSID1047813
29213000
Characteristics
26
4.05230
white crystalline solid
373-375 °C
247.8ºC at 760mmHg
99.3ºC
Freely soluble in water.
-20°C Freezer
0.0251mmHg at 25°C
Oral-rat LD50: 640 mg/kg;Abdominal cavity-mouse LD50: 135 mg/kg
Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes
146.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
22-36/37/38
26-36
AU4717000
Xn
Warehouse ventilated, low temperature and dry
P261-P305 + P351 + P338
H302-H315-H319-H335
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Compounds that inhibit cell production of DNA or RNA. (See all compounds classified as Nucleic Acid Synthesis Inhibitors.)
Flumadine
Rimantadine hydrochloride Use and Manufacturing
Used as an antiviral agent
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:215.76
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:215.1440774
Monoisotopic Mass:215.1440774
Topological Polar Surface Area:26
Heavy Atom Count:14
Complexity:180
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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