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Rimantadine hydrochloride

Rimantadine hydrochloride structure

CAS No:
1501-84-4
Formula:
C12H21N.ClH
Chemical Name:
Rimantadine hydrochloride
Synonyms:
Tricyclo[3.3.1.13,7]decane-1-methanamine,α-methyl-,hydrochloride (1:1);1-Adamantanemethylamine,α-methyl-,hydrochloride;Tricyclo[3.3.1.13,7]decane-1-methanamine,α-methyl-,hydrochloride;EXP 126;α-Methyl-1-adamantanemethylamine hydrochloride;Rimantadine hydrochloride;1-(1-Aminoethyl)adamantane hydrochloride;Remantadine;Meradan;Meradane;JP 61;Remantadin;Flumadine;Roflual;NSC 206764;1-(1-Adamantyl)ethylamine hydrochloride;1-(Adamantan-1-yl)ethan-1-amine hydrochloride;12710-47-3;33122-80-4
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

White Crystalline SolidRimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile.

Rimantadine hydrochloride is an organic molecular entity.|An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

Rimantadine hydrochloride Basic Attributes

Molecular Weight：

215.76

Exact Mass：

215.144073

EC Number：

1806241-263-5

NSC Number：

759149|206764

DSSTox ID：

DTXSID1047813

HScode：

29213000

Characteristics

PSA：

XLogP3：

4.05230

Appearance：

white crystalline solid

Melting Point：

373-375 °C

Boiling Point：

247.8ºC at 760mmHg

Flash Point：

99.3ºC

Water Solubility：

Freely soluble in water.

Storage Conditions：

-20°C Freezer

Vapor Pressure：

0.0251mmHg at 25°C

Toxicity：

Oral-rat LD50: 640 mg/kg;Abdominal cavity-mouse LD50: 135 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes

Collision Cross Section：

146.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-36

RTECS Number：

AU4717000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Compounds that inhibit cell production of DNA or RNA. (See all compounds classified as Nucleic Acid Synthesis Inhibitors.)

MeSH Entry Terms：

Flumadine

Rimantadine hydrochloride Use and Manufacturing

Uses

Used as an antiviral agent

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:215.76
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:215.1440774
Monoisotopic Mass:215.1440774
Topological Polar Surface Area:26
Heavy Atom Count:14
Complexity:180
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is an antiviral drug, mainly active against influenza A virus. It inhibits the proliferation of type A viruses in vitro, including H1N1, H2N2 and H3N2 subtypes isolated from humans. It has both preventive and therapeutic effects on animals infected with influenza A myxovirus. It may work early in the viral replication cycle by inhibiting the uncoating of viral particles in host cells. It does not suppress the immune response after exposure to influenza A virus. It has only a weak effect on other types of influenza viruses.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Rimantadine Hydrochloride Tablets
Ingredients	Chemical name: α-methyl-1-adamantanemethane hydrochloride Molecular weight: C12H22ClN
Indication	The chronic effect of cimetidine on the metabolism of rimantadine is unknown. When normal healthy adults took a single dose of 100 mg of this product and started taking cimetidine (300 mg four times a day) 1 hour later, the total apparent clearance of rimantadine after a single dose was reduced by 18% (compared with the total apparent clearance of rimantadine in subjects with the same conditions who did not take cimetidine). Paracetamol Several healthy volunteers took this product (100 mg, twice a day) for 13 days and paracetamol (650 mg, four times a day) on day 11 for 8 days. The pharmacokinetics of rimantadine were evaluated on days 11 and 13, and it was found that the peak plasma concentration and AUC value of rimantadine were reduced by about 11% after taking it with paracetamol. Aspartame
Specifications	0.1g
Manufacturer	NORTHEAST Pharmaceutical Group Shenyang NO.1 Pharmaceutical Co., Ltd.

Rimantadine Hydrochloride Oral Solution
Ingredients	Rimantadine Hydrochloride
Specifications	100 ml: 1 g

Rimantadine Hydrochloride Granules
Specifications	0.1g
Manufacturer	Jinling Pharmaceutical Co., Ltd. Nanjing Jinling Pharmaceutical Factory

See More Related Drugs

Registered Holders

Zhejiang Apeloa Kangyu Pharmaceutical Co., Ltd.

China
Active
NORTHEAST Pharmaceutical Group Co., Ltd.

China
Active
Olpha AS

United States
Active

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Guide of Rimantadine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

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