 Home > Encyclopedia > Oxybutynin hydrochloride

Oxybutynin hydrochloride

Oxybutynin hydrochloride structure

CAS No:
1508-65-2
Formula:
C22H31NO3.ClH
Chemical Name:
Oxybutynin hydrochloride
Synonyms:
Benzeneacetic acid,α-cyclohexyl-α-hydroxy-,4-(diethylamino)-2-butyn-1-yl ester,hydrochloride (1:1);Cyclohexaneglycolic acid,α-phenyl-,4-(diethylamino)-2-butynyl ester,hydrochloride;Benzeneacetic acid,α-cyclohexyl-α-hydroxy-,4-(diethylamino)-2-butynyl ester,hydrochloride;2-Butyn-1-ol,4-(diethylamino)-,α-phenylcyclohexaneglycolate (ester),hydrochloride;MJ 4309-1;4-(Diethylamino)-2-butynyl α-phenylcyclohexaneglycolate hydrochloride;Oxybutynin hydrochloride;Oxybutynin chloride;MJ 50-58;Tropax;Cystrin;Dridase;Pollakisu;Gelnique;Neoxy Tape;99937-06-1
Categories:
Active Pharmaceutical Ingredients > Urinary System Drugs

Description

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.Target: mAChROxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination (urge incontinence), by decreasing muscle spasms of the bladder. Oxybutynin competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth

Oxybutynin hydrochloride Basic Attributes

Molecular Weight：

393.95

Exact Mass：

393.207062

EC Number：

216-139-7

NSC Number：

759108

DSSTox ID：

DTXSID3045356

HScode：

2922509090

Characteristics

PSA：

49.8

XLogP3：

4.14490

Appearance：

white

Melting Point：

129.5 °C

Boiling Point：

494.4ºC at 760 mmHg

Water Solubility：

H2O: soluble 50mg/mL

Storage Conditions：

room temp

Vapor Pressure：

1.37E-10mmHg at 25°C

Collision Cross Section：

186.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

safety instructions：

RTECS Number：

GV2800000

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P333+P313, P337+P313, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 53 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. (See all compounds classified as Urological Agents.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

4-(diethylamino)-2-butynyl-alpha-cyclohexyl-alpha-hydroxybenzeneacetate

Oxybutynin hydrochloride Use and Manufacturing

Uses

An antagonist of M1, M2, & M3 muscarinic acetylcholine receptors Antispasmodic, used to treat urinary urgency, frequent urination, urinary incontinence, nocturia and enuresis

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:393.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:393.2070716
Monoisotopic Mass:393.2070716
Topological Polar Surface Area:49.8
Heavy Atom Count:27
Complexity:490
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Cyclohexanol

Drug Function and Efficacy

It has a direct spasmolytic effect on smooth muscle and can inhibit the muscarinic effect of acetylcholine on smooth muscle. It can selectively act on the detrusor muscle of the bladder, reduce the intra-bladder pressure, increase the bladder capacity, reduce involuntary bladder contractions and relieve urinary urgency, urinary frequency and urinary incontinence. It has no blocking effect on skeletal muscle ganglia and autonomic ganglia.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Oxybutynin Hydrochloride Extended Release Tablets
Ingredients	Oxybutynin Hydrochloride
Indication	1. The combined use of oxybutynin with other antispasmodics, other drugs that cause dry mouth, constipation, drowsiness or other anticholinergic drugs will increase the frequency and severity of the above symptoms; 2. Anticholinergic drugs affect the absorption of drugs taken at the same time due to their effects on gastrointestinal motility; 3. The data on the interaction between oxybutynin and P450 cytochrome enzyme inhibitors such as antifungal drugs (such as ketoconazole, itraconazole and miconazole), macrocyclic antibiotics (such as erythromycin, clarithromycin), etc. have not been established.
Specifications	10mg
Manufacturer	Nanjing Yewin Pharmaceutical Co., Ltd.

Oxybutynin Hydrochloride
Manufacturer	Qingdao Shouhejinhai Pharmaceutical Ltd.

Oxybutynin Hydrochloride
Manufacturer	Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

THINQ PHARMA-CRO LTD

United States
Active
APITORIA PHARMA PRIVATE LTD

United States
Active
Pcas

Japan
Active

See More Registered Holders

Recommended Suppliers of Oxybutynin hydrochloride

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Oxybutynin chloride USP 97%min supplier Pharmaceutical API Urinary system drugs made in china

CAS No.: 1508-65-2

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Oxybutynin hydrochloride

CAS No.: 1508-65-2

Content: 99.00%

Inquiry
bazayan Enterprises LLP Contact Supplier

IN
9 YRS

Business licensed

Trader Supplier

Oxybutynin HCL

CAS No.: 1508-65-2

Inquiry