2-bromo-6-chloro-phenol
-
2-bromo-6-chloro-phenol
structure -
-
CAS No:
2040-88-2
-
Formula:
C6H4BrClO
-
Chemical Name:
2-bromo-6-chloro-phenol
-
Synonyms:
2-Bromo-6-chlorophenol;Phenol, 2-bromo-6-chloro-;Phenol,2-bromo-6-chloro-;2-BROMO-6-CHLORO-PHENOL;PubChem17552;2-chloro-6-bromophenol;SCHEMBL2018126;CTK4E4145;KS-00000PNC;DTXSID40174350
-
CAS No:
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-bromo-6-chloro-phenol Use and Manufacturing
General procedure: Reaction conditions: Thiourea (5.1 molpercent, 2 mg, 0.026 mmol) was added to an acetonitrile solution (10 mL) containing NBS (1.15 equiv, 104.4 mg, 0.587 mmol). Anisole (56.3 mg, 0.51 mmol) was added immediately to the resulting stirred solution and allowed to stir at room temperature for 10 min. The reaction was quenched by the addition of 10percent aqueous solution of NaIn a nitrogen atmosphere, intermediate A-2 (45.5 g, 112.3 mmol) and In a nitrogen atmosphere, intermediate B-2 (47.5 g, 117.6 mmol) and Under the protection of nitrogen, magnetic stirring, intermediate A1: 56.3 g (122 mmol), In a 500 mL three-necked flask, the intermediate 7-c (10.8 g, 0.05 mol) obtained in the above step, In a 500 mL three-necked flask, under the protection of nitrogen, the intermediate 5-c (16.1 g, 0.05 mol) obtained from the above step, General procedure: Reaction conditions: Thiourea (5.1 mol%, 2 mg, 0.026 mmol) was added to an acetonitrile solution (10 mL) containing NBS (1.15 equiv, 104.4 mg, 0.587 mmol). Anisole (56.3 mg, 0.51 mmol) was added immediately to the resulting stirred solution and allowed to stir at room temperature for 10 min. The reaction was quenched by the addition of 10% aqueous solution of Na2S2O3 (10 mL) and extracted with ethyl acetate (70 mL). The organic solution was then washed with additional 10% Na2S2O3 (2 * 10 mL), followed by deionized water (3 * 15 mL) and brine (2 * 10 mL). The organic solution was then dried over anhydrous Na2SO4 and the solvent was evaporated in vacuo. The major product of each reaction was isolated by centrifugal thin-layer chromatography using a 2 mm thick silica gel 60GF254 coated plate (5% CH2Cl2/hexanes). The products reported herein are known compounds and were characterised by GC-MS, IR, 1H and 13C NMR. Their spectroscopic data are in agreement with those reported in the literature.
Computed Properties
Molecular Weight:207.45
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:205.91341
Monoisotopic Mass:205.91341
Topological Polar Surface Area:20.2
Heavy Atom Count:9
Complexity:99.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
