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Butizide

Butizide structure

CAS No:
2043-38-1
Formula:
C11H16ClN3O4S2
Chemical Name:
Butizide
Synonyms:
2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-3-(2-methylpropyl)-,1,1-dioxide;2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-3-isobutyl-,1,1-dioxide;Butizide;Eunephran;3-Isobutyl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Isobutylhydrochlorothiazide;Saltucin;Thiabutazide;Buthiazide;Su 6187;S 3500;Butizid;3500S;Modenol;96782-86-4
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Off-White Solid

Butizide is a benzothiadiazine.

Butizide Basic Attributes

Molecular Weight：

353.84500

Exact Mass：

353.85

EC Number：

218-048-8

DSSTox ID：

DTXSID6022713

Characteristics

PSA：

135.12000

XLogP3：

4.39210

Density：

1.433g/cm3

Melting Point：

221.5 °C

Boiling Point：

562.7ºC at 760mmHg

Flash Point：

294.1ºC

Refractive Index：

1.572

Storage Conditions：

Refrigerator

Vapor Pressure：

1.09E-12mmHg at 25°C

Drug Information

MeSH：

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

buthiazide

Butizide Use and Manufacturing

Diuretic and antihypertensive.

Computed Properties

Molecular Weight:353.8
XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:353.0270760
Monoisotopic Mass:353.0270760
Topological Polar Surface Area:135
Heavy Atom Count:21
Complexity:582
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes