N-(3-Aminophenyl)acetamide
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N-(3-Aminophenyl)acetamide
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CAS No:
102-28-3
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Formula:
C8H10N2O
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Chemical Name:
N-(3-Aminophenyl)acetamide
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Synonyms:
Acetamide,N-(3-aminophenyl)-;Acetanilide,3′-amino-;N-(3-Aminophenyl)acetamide;3′-Aminoacetanilide;1-Amino-3-(acetylamino)benzene;3-(Acetylamino)aniline;m-(Acetylamino)aniline;m-Aminoacetanilide;3-Amino-N-acetylaniline;N-Acetyl-m-phenylenediamine;m-Acetamidoaniline;N-Acetyl-1,3-diaminobenzene;3-Acetamidoaniline;1-Acetylamino-3-aminobenzene;NSC 165576;3-Acetylaminobenzeneamine;3-(Methylcarbonylamino)aniline
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CAS No:
Description
light brown crystalline powderGray solid.
M-aminoacetanilide is a gray solid. (NTP, 1992)
M-aminoacetanilide is a gray solid. (NTP, 1992)
Characteristics
55.1
0.9
M-aminoacetanilide is a gray solid. (NTP, 1992)
1.1392 (rough estimate)
70 °C
Decomposes at 1449° F (NTP, 1992)
189.0±23.2 °C
1.6180 (estimate)
H2O: 1-5 g/100 mL at 24 ºC
Store in a cool, dry place. Store in a tightly closed container.
2.96E-06mmHg at 25°C
Intravenous-Mouse LD50: 320 mg/kg
Flammable; burning produces toxic nitrogen oxide fumes
Soluble in water.
Amides and Imides
Aromatic amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Safety Information
III
IRRITANT
NONH for all modes of transport
3
36/37/38
26-36-37/39
AD8050000
Xi
Warehouse ventilated, low temperature and dry
P261-P305 + P351 + P338
H315-H319-H335
Flash point data concerning this compound are not available, however, it is probably combustible. (NTP, 1992)
|Warning|H302 (21.82%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 55 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Fires involving this compound can be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Drug Information
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
N-(3-Aminophenyl)acetamide Use and Manufacturing
Derived by acylation of m-phenylenediamine. Add water and m-phenylenediamine to the reaction pot to dissolve. Then add 30% hydrochloric acid, stir for half an hour, then add acetic acid, control the reaction temperature at 40°C, keep stirring for 1 hour, add refined salt for salting out, and filter. After neutralization, m-aminoacetanilide was obtained. The acylation operation may also use acetic anhydride as a raw material. The raw material consumption quota is 1021kg/t m-phenylenediamine, 1013kg/t acetic anhydride, and 475kg/t hydrochloric acid.
Dye intermediate. Mainly used to prepare reactive yellow K-RN and disperse dyes.
Acetamide, N-(3-aminophenyl)-: ACTIVE
Computed Properties
Molecular Weight:150.18
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:150.079312947
Monoisotopic Mass:150.079312947
Topological Polar Surface Area:55.1
Heavy Atom Count:11
Complexity:147
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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