Thieno[3,2-b]pyridine

Dissolve 7-bromo-thieno[3, 2-]pyridine (3.69 g, 17 mmol) in dry THF (20 mL) and cool to -78 3.69 g of 7-Bromo-thieno[3, 2-b]pyridine (17 mmol) is dissolved in 20 ml of dry THF and cooled to -782-Nitrothiophene (26 g, 200 mmol) was dissolved in 390 mL of concentrated hydrochloric acid and added portionwise under an ice bathTin powder(50 g, 420 mmol). After most of the tin powder had dissolved, 140 mL of ethanol and zinc chloride (12 g, 88 mmol) were added. The mix After the mixture was heated to 85 ° C, 1, 1, 3, 3-tetraethoxypropane (34.4 g, 156 mmol) was then added and the reaction was stirred at 85 ° CReaction for 1 hour. After the reaction was completed, the reaction was poured on ice, neutralized with ammonia to pH = 8 and extracted with dichloromethane After drying over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was chromatographed on silica gel using petroleum ether: ethyl acetate Ester (10: 1). Rotate the solvent to give 6.57 g of a colorless oily liquid, yield 24.3percent

Molecular Weight:135.19
XLogP3:2
Hydrogen Bond Acceptor Count:2
Exact Mass:135.01427034
Monoisotopic Mass:135.01427034
Topological Polar Surface Area:41.1
Heavy Atom Count:9
Complexity:105
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes