Ritalin

269.77

269.118256

206-065-3

1724

759278|169868

3249

DTXSID8020886

2933399090

38.33000

3.21610

Methylphenidate hydrochloride is an odorless white crystalline powder. Metallic taste. Solutions are acid to litmus. Absence of general acid/base catalysis. (NTP, 1992)

224-226 °C

327.6ºC at 760 mmHg

9℃

1.523

Soluble in alcohol, ethyl acetate, ether; practically insoluble in petroleum ether

Store at RT

5.89X10-5 mm Hg at 25 deg C (est)

LD50 orally in mice: 190 mg/kg (Greenblatt, Osterberg)

152.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Water soluble.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

METHYLPHENIDATE HYDROCHLORIDE is incompatible with alkalis and solutions of barbiturates (NTP, 1992). Undergoes typical ester hydrolysis in aqueous solutions at 176°F.

III

6.1(b)

3249

3

22-42-39/23/24/25-23/24/25-11

22-26-36-45-36/37-16

TM3850000

Xn,T,F

Stable. Combustible. Incompatible with strong oxidizing agents, alkalies, barbiturates.

P261-P342 + P311

H302-H334

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it at ambient temperatures. This compound is a Schedule II DEA Controlled Substance and is to be stored according to State and Federal Regulations. Refer to Code of Federal Regulations Title 21 Part 1300 to End. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Treatment of Attention Deficit Hyperactivity Disorder (ADHD)

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)|Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake. (See all compounds classified as Dopamine Uptake Inhibitors.)

SYMPTOMS: Symptoms of exposure to this chemical may include nausea, vomiting, nervousness, insomnia, dizziness, headache, blood pressure and pulse changes, anorexia, palpitations, dyskinesia, drowsiness, tachycardia, angina, cardiac arrhythmia, abdominal pain and weight loss. It may also cause hypersensitivity, including skin rash, urticaria, fever, arthralgia, exfoliative dermatitis, erythema multiforme with histopathological findings of necrotizing vasculitis and thrombocytopenia purpura. Exposure to this compound may cause multiple small retinal emboli and a rise in ocular pressure in glaucomatous patients. Other symptoms include difficulties with accommodation and blurring of vision, Tourette`s syndrome, toxic psychosis, leukopenia, anemia, scalp hair loss, agitation, tremors, hyperreflexia, muscle twitching, convulsions which may be followed by coma, euphoria, confusion, hallucinations, delirium, sweating, flushing, hyperpyrexia, hypertension, mydriasis and dryness of mucous membranes. It also causes dryness of the mouth, constipation or diarrhea, difficulty in micturition, restlessness, changes in libido, talkativeness, disorientation, aggressive behavior, fatigue, mental depression which may be followed by convulsions and coma, aplastic anemia, acute conjunctivitis, pancytopenia, hypotension, angioneuroti edema, paranoid psychosis, lethargy, sleepiness and akathisia. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes of hydrogen chloride and NOx. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Centedrin

Methylphenidate|Concerta, Ritalin, Methylin|1724|Schedule II - Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|No

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients