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Ungeremine

Ungeremine structure

CAS No:
2121-12-2
Formula:
C16H12NO3
Chemical Name:
Ungeremine
Synonyms:
[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridinium,4,5-dihydro-2-hydroxy-;Lycoranium,1,2,3,3a,6,7,12b,12c-octadehydro-2-hydroxy-;4,5-Dihydro-2-hydroxy[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridinium;Ungeremine;Lycobetaine;Ungerimine;6883-38-1;72510-04-4
Categories:
Organic Chemistry > Amides

Description

Ungeremine, a phenanthridine type alkaloid, is extracted of the bulbs of Pancratium Illyricum. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. Ungeremine displays cytotoxic activity towards the 9 cancer cell lines, including drug-sensitive and MDR phenotypes. Ungeremine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production[1][2].

Ungeremine Basic Attributes

Molecular Weight：

266.276

Exact Mass：

266.08200

DSSTox ID：

DTXSID50175439

Characteristics

PSA：

42.6

XLogP3：

2.27090

Density：

1.1727 (rough estimate)

Melting Point：

270-272 °C (decomp)

Drug Information

MeSH Entry Terms：

AT 1840

Computed Properties

Molecular Weight:266.27
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:266.08171824
Monoisotopic Mass:266.08171824
Topological Polar Surface Area:42.6
Heavy Atom Count:20
Formal Charge:1
Complexity:403
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes