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2-Amino-3-methylpyridine

2-Amino-3-methylpyridine structure

CAS No:
1603-40-3
Formula:
C6H8N2
Chemical Name:
2-Amino-3-methylpyridine
Synonyms:
2-Pyridinamine,3-methyl-;3-Picoline,2-amino-;3-Methyl-2-pyridinamine;2-Amino-3-picoline;2-Amino-3-methylpyridine;2-Amino-β-picoline;3-Methyl-2-aminopyridine;3-Methylpyridin-2-ylamine;NSC 176169;NSC 450
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

2-Amino-3-picoline is CLEAR YELLOW LIQUID AFTER MELTING

2-Amino-3-methylpyridine Basic Attributes

Molecular Weight：

108.14

Exact Mass：

108.14

BRN：

107892

EC Number：

216-501-4

UNII：

Y2WWD85QY6

NSC Number：

450

DSSTox ID：

DTXSID3051759

HScode：

29333999

Characteristics

PSA：

38.9

XLogP3：

0.9

Appearance：

Clear yellow Liquid After Melting

Density：

1.073 g/mL at 25 °C(lit.)

Melting Point：

33.5 °C

Boiling Point：

222 °C

Flash Point：

233 °F

Refractive Index：

n 20/D 1.5823(lit.)

Water Solubility：

H2O: soluble

Storage Conditions：

Store below +30°C.

Vapor Pressure：

0.11mmHg at 25°C

Toxicity：

Oral-rat LD50: 100 mg/kg; Subcutaneous-mouse LD50: 36 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Packing level：

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

23/24/25-33-36/37/38-25

safety instructions：

36/37/39-45-37/39-28A-26

RTECS Number：

US1850000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P301 + P310-P311

Hazard Statements：

H301-H311-H331-H373

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P280, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P310, P311, P312, P314, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH Entry Terms：

2-amino-3-methylpyridine

2-Amino-3-methylpyridine Use and Manufacturing

Methods of Manufacturing

1) Add 9021g of toluene, 538g of sodium metal, 70g of ethanolamine and 1900g of 3-picoline to the autoclave. After tightening the autoclave, open the autoclave inlet and the addition port of the dropping tank, and open the dropping tank And the kettle body valve, the hose through the feeding port into the bottom of the tank, with nitrogen replacement air for 1min, closed the lid of the feeding port, warmed to 60 , dropping liquid ammonia, control the pressure in the autoclave 3MPa, the final Liquid ammonia added amount of 600g. Fully respond.
2) The temperature was raised to 170 ° C, nitrogen was filled to a pressure of 5 MPa, and the reaction was sufficiently completed. When the pressure in the autoclave increased to 5.5 MPa, Pressure relief to 5MPa, repeat this operation until the pressure inside the reactor does not rise as the end of the reaction, down to room temperature.
3) The ammoniated liquid was taken out and slowly added dropwise to water (9 kg). The mixture was stirred and hydrolyzed and extracted, and the mixture was allowed to stand still. After the aqueous phase was extracted again with 3 L of toluene, the oil phases were combined and the oil phase was quantified by gas chromatography.Among them, 1928g of 2-amino-5-methylpyridine and 144g of 2-amino-3-methylpyridine.

Uses

2-Amino-3-methylpyridine is used in the synthesis of ketones from aldehydes.

Manufacturing Info：

2-Pyridinamine, 3-methyl-: ACTIVE

Computed Properties

Molecular Weight:108.14
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:108.068748264
Monoisotopic Mass:108.068748264
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:72.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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