(+)-MAGNOFLORINE IODIDE
-
(+)-MAGNOFLORINE IODIDE
structure -
-
CAS No:
2141-09-5
-
Formula:
C20H24INO4
-
Chemical Name:
(+)-MAGNOFLORINE IODIDE
-
Synonyms:
(+)-MAGNOFLORINE IODIDE;MAGNOFLORINE IODIDE, (+)-;1,11-dihydroxy-2,10-dimethoxy-6-methyl-6a-alpha-aporphiniu;escholin;escholine;g)quinolinium,5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-4h-dibenzo(d;THALICTRIN;THALICTRINE
- Categories:
-
CAS No:
Description
(+)-Magnoflorine (Magnoflorine) is an aporphine alkaloid found in Acoruscalamus, with anti-fungal activity, reduces the formation of C. albicans’ biofilm[1]. Anti-antidiabeticand anti-oxidative activity[2].
(S)-magnoflorine is an aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group. It has a role as a plant metabolite. It is an aporphine alkaloid and a quaternary ammonium ion. It derives from a (S)-corytuberine.
A wide variety of species contain this quaternary alkaloid which is widespread among the families, Aquilegia, Magnolia and Michelia. It has been isolated and characterized as the iodide, m.p. 248-9°C (dec.); [0:11>5 + 200.1° (MeOH). The optically inactive base also yields an iodide which crystallizes with 1.5 H20, m.p. 243°C (dec.).
Magnoflorine is an alkaloid and a major constituent ofS. acutumthat has diverse biological activities. It reduces hemolysis induced by lysophosphatidylcholine (LPC), but not NaCl, in a rat erythrocyte suspension when used at concentrations ranging from 0.01 to 10 μM. Magnoflorine (10 μM) induces intracellular chloride influx in neuroblastoma cells, an effect that is reversed by the GABAAreceptor antagonist bicuculline . It reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells.In vivo, magnoflorine (20 mg/kg, i.p.) improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment.
Off-white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from magnolia, thrush, phellodendron, coptis root, celandine and magnolia.
Safety Information
NONH for all modes of transport
WGK 3
HQ1777600
P261-P280-P301 + P312 + P330-P302 + P352 + P312-P304 + P340 + P312
H302 + H312 + H332
(+)-MAGNOFLORINE IODIDE Use and Manufacturing
Magnoflorine-d3 is the labelled analogue of Magnoflorine, an isoquinoline alkaloid from the Coptis japonica and it enhances the myoblast differentiation through activation of the p38 MAP kinase and Akt pathway.
Computed Properties
Molecular Weight:342.4
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:342.17053325
Monoisotopic Mass:342.17053325
Topological Polar Surface Area:58.9
Heavy Atom Count:25
Formal Charge:1
Complexity:498
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of (+)-MAGNOFLORINE IODIDE
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
8 YRS
Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 2141-09-5Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamineInquiryCAS No.: 2141-09-5Grade: Industrial GradeContent: 99%
Learn More Other Chemicals
-
2,4-DICHLOROBENZYL IODIDE
116529-35-2
-
1H-Imidazo[4,5-b]quinoxalinium, 2-[2-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)ethenyl]-1,3-di-2-propen-1-yl-, iodide (1:1)
23427-51-2
-
Germanium iodide (GeI2)
13573-08-5
-
2-Propyn-1-aminium, N,N,N-trimethyl-, iodide (1:1) Formula
7383-74-6
-
Acridinium, 9-amino-10-methyl-, iodide (1:1) Formula
36141-84-1
-
1-Propanaminium, 2-hydroxy-N,N-dimethyl-N-(1-methylethyl)-3-(1-naphthalenyloxy)-, iodide (1:1) Formula
38726-81-7
-
1-Methyl-4,4′-bipyridinium iodide Structure
38873-01-7
-
Benzenaminium, 4-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-2-(1-methylethyl)-, iodide (1:1) Structure
63981-53-3
-
What is Ethanaminium, N-ethyl-2-hydroxy-N,N-dimethyl-, iodide (1:1)
1113-04-8
-
What is Naphtho[2,1-f]quinolinium, 1,2,3,4,4a,4b,5,7,8,9,10,10a,10b,11,12,12a-hexadecahydro-1,1,10a,12a-tetramethyl-8-(1-methylpyrrolidinio)-, iodide (1:2), (4aS,4bR,8S,10aR,10bS,12aS)-
54278-85-2