Carbitol acetate

176.21

176.21

1764643

203-940-1

W5EIM81UBX

8702

DTXSID6026905

Colorless liquid

29189090

44.8

0.32 (est)

White to slightly beige Crystalline Powder, Crystals and/or Chunks

1.0096 g/cm³ @ Temp: 20 °C

-25 °C

218.5 °C

203 °F

1.4206-1.4226

H2O: soluble

Store below +30°C.

9.89X10-2 mm Hg at 20 deg C

6.07 (Air = 1)

Oral-rat LD50: 11000 mg/kg

In case of heat, the oxidant is flammable; thermal decomposition is spicy and stimulates smoke

1.5%(V)

Characteristic: quality: sweet; hedonic tone: pleasant to unpleasant.

BITTER

Henry's Law constant = 2.3X10-8 atm-cu m/mol at 25 °C (est)

Conversion factors: 1 ppm = 7.20 mg/cu m; 1 mg/L = 139 ppm|Hygroscopic|Coefficient of expansion: 0.00105 at 20 °C|Percent in saturated air at 25 °C, 760 mm Hg: 0.01|For more Other Experimental Properties (Complete) data for 2-(2-ETHOXYETHOXY)ETHYL ACETATE (6 total), please visit the HSDB record page.

No rapid reaction with air No rapid reaction with water

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

DIETHYLENE GLYCOL ETHYL ETHER ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

2-(2-Ethoxyethoxy)ethyl acetate|D: Other compounds that may form peroxides|Kelly

563 °F (295 °C)

Lower 0.76% at 275 °F; upper 5.0% at 365 °F

NONH for all modes of transport

1

19-36/37/38-36/37-36

26-36-39

KK8925000

Xi

Treasury is ventilated and dry at low temperature; stored separately from oxidants

Very low volatility

P305 + P351 + P338

H319

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

... Can react with oxidizing materials.

Diethylene glycol monoethyl ether acetate is an indirect food additive for use only as a component of adhesives.

OECD; SIDS Initial Assessment Report for SIAM 21. Washington, DC, 18-21 October 2005

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon dioxide and carbon monoxide, may be formed when involved in fire. (USCG, 1999)

|Warning|H319 (99.73%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 832 companies from 10 notifications to the ECHA C&L Inventory.

Full impervious protective clothing, including boots and gloves. Where splashing is possible wear full face shield or chemical safety goggles. Use approved respirator to protect against vapors. (USCG, 1999)

Combustible when exposed to heat ...

To fight fire, use alcohol foam, water, CO2, dry chemical.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

A skin and eye irritant.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diethylene glycol monoethyl ether acetate is produced, as an intermediate or a final product, by process units covered under this subpart.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.

Diethylene glycol monoethyl ether acetate was identified as a solvent in 4 samples of serigraphy printer's inks at concentrations ranging from 0.1 to 33.9% w/w(1).

practically nontoxic

LD50 Rat oral 11 g/kg|LD50 Rabbit skin 15.1 mL/kg|LD50 Guinea pig oral 3930 mg/kg|LD50 Rabbit oral 4.4 g/kg

Diethylene glycol monoethyl ether acetate's production and use as a solvent for cellulose esters, gums, resins, coatings and lacquers, and printing inks(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from an assigned value for water solubility of 1X10+6 mg/L (miscible)(2) and a regression-derived equation(3), indicates that diethylene glycol monoethyl ether acetate is expected to have very high mobility in soil(SRC). Volatilization of 2-(2-ethyoxyethoxy)ethyl acetate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.3X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 9.89X10-2 mm Hg(4), and assigned value for water solubility(2). Diethylene glycol monoethyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Utilizing the Japanese MITI test, 98-103% of the theoretical BOD was reached over a 4 week incubation period using an activated sludge and an initial chemical concentration of 100 mg/L(5), indicating that biodegradation in soil is an important environmental fate process(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from an assigned value for water solubility of 1X10+6 mg/L (miscible)(2) and a regression-derived equation(3), indicates that diethylene glycol monoethyl ether acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.3X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 9.89X10-2 mm Hg(4), and assigned value for water solubility(2). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Estimated hydrolysis half-lives of 300 and 30 days at pHs 7 and 8, respectively(8), suggest that hydrolysis is only expected to be an important process under alkaline conditions(SRC). Utilizing the Japanese MITI test, 98-103% of the theoretical BOD was reached over a 4 week incubation period using an activated sludge and an initial chemical concentration of 100 mg/L(9), indicating that biodegradation in soil is an important environmental fate process(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol monoethyl ether acetate, which has a vapor pressure of 9.89X10-2 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol monoethyl ether acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its rate constant of 2.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Diethylene glycol monoethyl ether acetatecontains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of diethylene glycol monoethyl ether acetate with photochemically-produced hydroxyl radicals has been estimated as 2.9X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 13 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.26 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 300 and 30 days at pH values of 7 and 8, respectively(2). Diethylene glycol monoethyl ether acetate contains chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for diethylene glycol monoethyl ether acetate(SRC), using an estimated log Kow of 0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of diethylene glycol monoethyl ether acetate is estimated as 10(SRC), using an assigned value for water solubility of 1X10+6 mg/L (miscible)(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diethylene glycol monoethyl ether acetate is expected to have very high mobility in soil.

The Henry's Law constant for diethylene glycol monoethyl ether acetate is estimated as 2.3X10-8 atm-cu m/mole(SRC) derived from its vapor pressure, 9.89X10-2 mm Hg(1), and assigned value for water solubility of 1X10+6 mg/L (miscible)(2). This Henry's Law constant indicates that diethylene glycol monoethyl ether acetate is expected to be essentially nonvolatile from water surfaces(3). Diethylene glycol monoethyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 18,136 workers (4,675 of these were female) were potentially exposed to diethylene glycol monoethyl ether acetate in the US(1). Occupational exposure to diethylene glycol monoethyl ether acetate may occur through inhalation and dermal contact with this compound at workplaces where diethylene glycol monoethyl ether acetate is produced or used. Use data indicate that the general population may be exposed to diethylene glycol monoethyl ether acetate via dermal contact with products containing diethylene glycol monoethyl ether acetate(SRC).

The present investigation has examined the metabolism, elimination, and regional brain distribution of (14C)- tris(2-chloroethyl) phosphate (TRCP) in male and female rats. [14C]TRCP was administered by gavage (0, 175, 350, or 700 mg/kg) and urine, feces, exhaled volatiles, CO2, and selected tissues were collected. Regional brain distribution of 14C was determined 2 hr following single doses of TRCP to male and female rats, and 24 hr after a single dose and the last of 14 daily doses of TRCP to female rats. Results of these studies indicate that TRCP is readily absorbed from the gastrointestinal tract, distributed to all brain regions, and that metabolism and excretion are nearly complete in 72 hr. Most of the TRCP-derived radioactivity was excreted in urine (up to 85%), with feces, volatiles, and CO2 combined accounting for less than 10% of the dose. Predominant signs of toxicity associated with TRCP administration (350 and 700 mg/kg) were seizures within 2 hr of treatment, when most of the TRCP-derived radioactivity present in brain tissue was in the form of the parent compound. Traces of inextractable 14C were detected at later times, but this material was not concentrated in brain relative to other tissues.

Tris(2-chloroethyl) phosphate (TRCP) ... produces a dose-, sex-, and species-dependent lesion in the hippocampal region of the brain following subchronic oral administration. This lesion is more common and more severe in female F344 rats than in male F344 rats, and is not observed in B6C3F1 mice. The present investigation of the metabolism of TRCP was designed to detect sex and species variations that might account for differences in toxicity. Elimination of TRCP-derived radioactivity was more rapid in mice, which excreted greater than 70% of an oral dose of 175 mg/kg in urine in 8 hr vs approximately 40% for male or female rats. However, the metabolic profile of TRCP-derived radioactivity in urine was similar for both species. The major metabolite in female rat urine was identified as bis(2-chloroethyl) carboxymethyl phosphate. This metabolite co-chromatographed with the major metabolite found in both male rat and mouse urine. Two additional metabolites identified in female rat urine were bis(2-chloroethyl) hydrogen phosphate and the glucuronide of bis(2-chloroethyl) 2-hydroxyethyl phosphate. These metabolites also cochromatographed with metabolites found in male rat and mouse urine. TRCP metabolism in rats was not induced or inhibited by nine daily 175 mg/kg doses. Toxicity, as evidenced by seizures, was potentiated in male rats pretreated with inhibitors of aldehyde dehydrogenase.|These esters are apparently saponified (eg, hydrolyzed) in the body to the glycol ether (= carbitol) & an organic acid. /Carbitol esters/

Exposure can cause irritation of eyes, nose and throat. (USCG, 1999)

Get medical attention. INHALATION: Remove to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen. EYES: Flush with water for at least 15 min., lifting lids occasionally. SKIN: Remove contaminated clothing and shoes. Wash with soap and water. (USCG, 1999)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

/HUMAN EXPOSURE STUDIES/ Diethylene glycol monoethyl ether acetate (DGEEA) ... produces only a mild irritation when tested on humans.|/SIGNS AND SYMPTOMS/ Human patch tests, using undiluted material, resulted in limited number of people developing mild skin irritation.|/SIGNS AND SYMPTOMS/ Symptomatology: 1. Central nervous depression... 3. Nausea, vomiting, & sometimes diarrhea. 4. ...Headache. Later abdominal & lumbar pain & costovertebral angle tenderness. 5. Transient polyuria & then oliguria, progressing to anuria. 6. Acute renal failure... /Diethylene glycol & its ether-esters/|/SIGNS AND SYMPTOMS/ Symptomatology: 7. Less critical pathological lesions may appear in brain, lungs, liver, meninges & heart. /Diethylene glycol & its ether-esters/

Grade: Technical

All other basic organic chemical manufacturing|Ethanol, 2-(2-ethoxyethoxy)-, 1-acetate: ACTIVE

Method: OSHA PV2013; Procedure: gas chromatography with a flame ionization detector; Analyte: carbatol acetate; Matrix: air; Detection Limit: 5 ug/mL.

Cosmetics -> Solvent