4,5-DIMETHYL-1,3-THIAZOL-2-AMINE

Equipped with a stirrer, a condenser and a constant pressure funnel 250 ml three-necked flask, 43.27 g, 0.6 mol XVI butanoneand 36percent HCl 30.42 g, 0.3 mole, was added 8.1 grams of copper chloride, 0.06 moles of a 35 degrees Celsius, was slowlyadded dropwise within 15 minutes 30percent h 2 O 2 49.23 g, 0.39 mol, after completion, the reaction was warmed to 78 ° C reflux for5 hours, the reaction mixture was cooled to room temperature, the organic phase was separated, washed with saturated sodiumcarbonate solution was washed twice, dried over anhydrous sodium sulfate, distillation to collect 137-140 ° C fraction, to give abrown liquid chloroprene -one 3- XVII8.0 g, yield 12.6percent; 100 ml round bottom flask was added 30 ml of ethanol and thiourea 3.5g, 47 mmol, heated at reflux with stirring until dissolution of thiourea, 5.0 g, 47 mmoles 3- after ketone XVII chlorobutanol, refluxed overnight, concentrated to remove the ethanol yield a crude yellow solid, 30 ml of methylene dissolved methane, washed with saturated sodium carbonate solution, the organic layer was collected, dried over anhydrous sodium sulfate, andconcentrated to give a yellow oil which was mixed with solid 2-amino-3, 4-dimethyl-thiazole XVIII3.8 g, yield 63.3percent.

Molecular Weight:128.20
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:128.04081944
Monoisotopic Mass:128.04081944
Topological Polar Surface Area:67.2
Heavy Atom Count:8
Complexity:86.5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes