Hydroxyzine hydrochloride
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Hydroxyzine hydrochloride
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CAS No:
2192-20-3
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Formula:
C21H27ClN2O2.2ClH
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Chemical Name:
Hydroxyzine hydrochloride
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Synonyms:
Ethanol,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,hydrochloride (1:2);Ethanol,2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-,dihydrochloride;Ethanol,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,dihydrochloride;Atarax dihydrochloride;1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine dihydrochloride;2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol dihydrochloride;Hydroxyzine dihydrochloride;Vistaril Steraject;Atarax;Hydroxyzine hydrochloride;Neurolax;Durrax;Quiess;Hydroxyzyne hydrochloride;Alamon;Orgatrax;Vistaril Parenteral;QYS;Aterax;Atranine A;Atarax P Parenteral soln.;Hydroxizine chloride;2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride
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CAS No:
Description
Hydroxyzine Dihydrochloride is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine (500 M) significantly increases transpo
A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
Characteristics
35.9
4.53570
powder
1.182 g/cm3
193 °C
499.2°C at 760 mmHg
9℃
H2O: soluble
Refrigerator
1.17X10-11 mm Hg at 25 deg C (est)
LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)
Safety Information
UN1230 - class 3 - PG 2 - Methanol, solution
3
22-36/37/38
26
KK2280000
Xn
P301 + P312 + P330-P305 + P351 + P338
H302-H315-H319-H335
Drug Information
Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)
2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol
Hydroxyzine hydrochloride Use and Manufacturing
H1 receptor antagonist. Anxiolytic. Antihistaminic.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:411.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:410.1527835
Monoisotopic Mass:410.1527835
Topological Polar Surface Area:35.9
Heavy Atom Count:27
Complexity:376
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has central sedative, weak antianxiety and muscle relaxant effects, and has antihistamine effects
Registered Holders
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SRIKEM LABORATORIES PVT LTD
Active
United States
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FLEMING LABORATORIES LTD
Active
United States
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GLOCHEM INDUSTRIES PRIVATE LTD
Active
United States
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