Hydroxyzine dihydrochloride
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Hydroxyzine dihydrochloride
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CAS No:
2192-20-3
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Formula:
C21H29Cl3N2O2
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Chemical Name:
Hydroxyzine dihydrochloride
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Synonyms:
ateraxdihydrochloride;dichlorhydratede1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine;neurolax;orgatrax;tran-qdihydrochloride;Disron;Hydroxyzine Hydrochloride (500 mg);Hydroxyzine Di Hcl
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CAS No:
Description
Hydroxyzine Dihydrochloride is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine (500 M) significantly increases transpo
A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
White Solid
Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydroxyzine dihydrochloride Basic Attributes
447.83
446.129456
218-586-3
TSCA listed
DTXSID5047530
White to Off-White
29335990
Characteristics
35.9
4.53570
powder
1.182 g/cm3
190-192°C
499.2°C at 760 mmHg
9℃
H2O: solublealcohol: solublechloroform: soluble
Refrigerator
1.17X10-11 mm Hg at 25 deg C (est)
LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)
2-8°C
Safety Information
UN1230 - class 3 - PG 2 - Methanol, solution
3
Xn
26
KK2280000
Xn
P301 + P312 + P330-P305 + P351 + P338
22-36/37/38
Drug Information
Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)
2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol
Hydroxyzine dihydrochloride Use and Manufacturing
H1 receptor antagonist. Anxiolytic. Antihistaminic.
Antihistaminic;H1 antogonist
Anti histamines
Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:411.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:410.1527835
Monoisotopic Mass:410.1527835
Topological Polar Surface Area:35.9
Heavy Atom Count:27
Complexity:376
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has central sedative, weak antianxiety and muscle relaxant effects, and has antihistamine effects
Registered Holders
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SRIKEM LABORATORIES PVT LTD
Active![United States]()
United States
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FLEMING LABORATORIES LTD
Active![United States]()
United States
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GLOCHEM INDUSTRIES PRIVATE LTD
Active![United States]()
United States
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