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Mofebutazone

Mofebutazone structure

CAS No:
2210-63-1
Formula:
C13H16N2O2
Chemical Name:
Mofebutazone
Synonyms:
3,5-Pyrazolidinedione,4-butyl-1-phenyl-;4-Butyl-1-phenyl-3,5-pyrazolidinedione;Mofebutazone;1-Phenyl-4-butyl-3,5-pyrazolidinedione;Butazone;Mobutazone;Monazan;Monophenylbutazone;1-Phenyl-4-n-butyl-3,5-dioxopyrazolidine;Mophebutazone;4-Butyl-3,5-dioxo-1-phenyltetrahydropyrazole;4-Butyl-1-phenyl-3,5-dioxopyrazolidine;2-Phenyl-3,5-dihydroxy-4-butylpyrazolidine;Mobutazon;Mobuzon;Reumatox;Monorheumetten;1-Phenyl-4-butylpyrazolidin-3,5-dione;Arcobutine;Monomil;Monozon;Mozol;Monofen;Arcomonol Tablets;Mofesal;Monobutyl;Monazon;NSC 73725;Monofenew;29211-39-0
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

ChEBI: A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.

Mofebutazone is a pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain. It has a role as a non-steroidal anti-inflammatory drug and a non-narcotic analgesic.

Mofebutazone Basic Attributes

Molecular Weight：

232.283

Exact Mass：

232.28

EC Number：

218-641-1

NSC Number：

73725

DSSTox ID：

DTXSID4023331

ATC Code：

M - Musculo-skeletal system

HScode：

2933990090

Characteristics

PSA：

49.4

XLogP3：

2.26460

Density：

1.14g/cm3

Melting Point：

102.5 °C

Refractive Index：

1.541

Toxicity：

LD50 i.v. in mice: 600 mg/kg (Schoetensack)

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

1-phenyl-4-n-butyl-3,5-dioxopyrazolidine

Mofebutazone Use and Manufacturing

Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.

Computed Properties

Molecular Weight:232.28
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:232.121177757
Monoisotopic Mass:232.121177757
Topological Polar Surface Area:49.4
Heavy Atom Count:17
Complexity:298
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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MOFEBUTAZONE

CAS No.: 2210-63-1

Grade: industrial Grade

Content: 98%

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