1-Chloro-2,5-difluorobenzene
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1-Chloro-2,5-difluorobenzene
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CAS No:
2367-91-1
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Formula:
C6H3ClF2
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Chemical Name:
1-Chloro-2,5-difluorobenzene
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Synonyms:
1-Chloro-2,5-difluor;2,5-DIFLUOROCHLOROBENZENE;1-CHLORO-2,5-DIFLUOROBENZENE;2-CHLORO-1,4-DIFLUOROBENZENE;2,5-Difluorochlorobenzene98%;Benzene,2-chloro-1,4-difluoro-;1-Chloro-2,5-difluorobenzene98%;1-CHLORO-25-DIFLUOROBENZENE98%;1-Chloro-2,5-difluorobenzene2,5-Difluorochlorobenzene;1-Chloro-2,5-difluorobenzene,2-Chloro-1,4-difluorobenzene
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CAS No:
1-Chloro-2,5-difluorobenzene Basic Attributes
148.54
147.989136
2081082
-0
10253
DTXSID70178341
2903999090
Safety Information
Ⅲ
3
UN 1993 3/PG 2
3
10-20/21/22-36/37-36/37/38-11
16-26-36-37/39
Xn,F,Xi
Flammable
P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501
H225
|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-Chloro-2,5-difluorobenzene Use and Manufacturing
General procedure: A FEP or PFA reactor equipped with a Teflon-lined magnetic stir bar and connected to a gas-washing bottle was charged with substituted benzene (0.95–1.10 mmol), 1, 1, 1, 3, 3-pentafluorobutane (1–2 mL per mmol of C6H5R), and BF3 · Et2O (1.3–1.5 mmol per mmol of C6H5R). The mixture was stirred for 10–15 min at 0–5°C (ice bath), and XeF2 (1.2–1.3 mmol per mmol of C6H5R) was added in portions. After addition of each portion, the mixture was stirred for 3–5 min at 22–25°C and cooled again. When the addition was complete the dark solution was stirred for 15–30 min at 22–25°C, 10percent aqueous KHCO3 was added, and the upper organic layer was separated, passed through a short column charged with silica gel (40–60 μm), and dried over MgSO4. The solution was analyzed by 19F NMR and GC/MS. The main products are given in table, and the others are listed below (GC/MS data).
Computed Properties
Molecular Weight:148.54
XLogP3:2.8
Hydrogen Bond Acceptor Count:2
Exact Mass:147.9891341
Monoisotopic Mass:147.9891341
Heavy Atom Count:9
Complexity:97.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 1-Chloro-2,5-difluorobenzene
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Business licensedTrader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic AcidInquiryCAS No.: 2367-91-1Grade: Pharmaceutical GradeContent: 99%
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