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Antazoline hydrochloride

Antazoline hydrochloride structure

CAS No:
2508-72-7
Formula:
C17H19N3.ClH
Chemical Name:
Antazoline hydrochloride
Synonyms:
1H-Imidazole-2-methanamine,4,5-dihydro-N-phenyl-N-(phenylmethyl)-,hydrochloride (1:1);1H-Imidazole-2-methanamine,4,5-dihydro-N-phenyl-N-(phenylmethyl)-,monohydrochloride;2-Imidazoline,2-[(N-benzylanilino)methyl]-,monohydrochloride;Antazoline hydrochloride;Antistine hydrochloride;2-(N-Benzylanilinomethyl)-2-imidazoline hydrochloride;Phenazoline hydrochloride;Antazoline chloride;Antistina;Antistin;Antastan;Histostab;Antihistal;Imidamine;Azalone;Antasten;Dibistin;5512M;Fenazolina;Histazine;Ben-a-hist
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Antazoline hydrochloride is a 1st generation antihistamine with also anticholinergic properties used to relieve nasal congestion and in eye drops.

An antagonist of histamine H1 receptors.

Antazoline hydrochloride Basic Attributes

Molecular Weight：

301.81

Exact Mass：

301.134583

EC Number：

219-719-8

UNII：

FP8Q8F72JH

DSSTox ID：

DTXSID1047782

HScode：

2933290090

Characteristics

PSA：

27.6

XLogP3：

3.26130

Appearance：

White or almost white crystalline powder

Melting Point：

237-241 °C

Boiling Point：

475.5°C at 760 mmHg

Flash Point：

241.4ºC

Water Solubility：

>45.3 [ug/mL]

Storage Conditions：

Store at RT

Vapor Pressure：

3.31E-09mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

26-36

RTECS Number：

NJ2150000

Marks：

Xn,Xi

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H312-H315-H319-H332-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

MeSH Entry Terms：

Analergine

Antazoline hydrochloride Use and Manufacturing

Imidazoline binding site ligand and an antihistamine

Computed Properties

Molecular Weight:301.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:301.1345753
Monoisotopic Mass:301.1345753
Topological Polar Surface Area:27.6
Heavy Atom Count:21
Complexity:314
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has antiarrhythmic effects, and its mechanism of action is to interfere with the permeability of myocardial cell membranes to sodium and potassium ions, slowing down myocardial conduction; at the same time, it has a mild sympathetic nerve blocking effect, thereby increasing peripheral vascular resistance and reducing cardiac output, with no effect on blood pressure and heart rate, and the action time can last for 4 to 6 hours.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Antazoline Hydrochloride Tablets
Ingredients	Antazoline hydrochloride.
Indication	Not yet clear.
Specifications	0.1 g
Manufacturer	Shanghai Yurui BIOTECHNOLOGY (Anyang) Pharmaceutical Co., Ltd.

Registered Holders

Shanghai Yurui BIOTECHNOLOGY (Anyang) Pharmaceutical Co., Ltd.

China
Active
METROCHEM API PRIVATE LIMITED

European Union
Active

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