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Propamidine

Propamidine structure

CAS No:
104-32-5
Formula:
C17H20N4O2
Chemical Name:
Propamidine
Synonyms:
Benzenecarboximidamide,4,4′-[1,3-propanediylbis(oxy)]bis-;Benzamidine,4,4′-(trimethylenedioxy)di-;4,4′-[1,3-Propanediylbis(oxy)]bis[benzenecarboximidamide];Propamidine;p,p′-(Trimethylenedioxy)dibenzamidine;4,4′-(Trimethylenedioxy)dibenzamidine;M. & B. 782;Panamidin;DAPP
Categories:
Chemical Reagents > Organic Reagents

Description

ChEBI: A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.

Propamidine is a polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis. It has a role as an antimicrobial agent and an antiseptic drug. It is a member of guanidines, an aromatic ether and a polyether. It derives from a propane-1,3-diol. It is a conjugate base of a propamidine(2+).

Propamidine Basic Attributes

Molecular Weight：

312.37

Exact Mass：

312.37

EC Number：

203-195-2

UNII：

G20G12V769

DSSTox ID：

DTXSID6048674

ATC Code：

D - Dermatologicals|S - Sensory organs

HScode：

2925290012

Characteristics

PSA：

118

XLogP3：

1.62

Density：

1.3±0.1 g/cm3

Boiling Point：

497.3±55.0 °C at 760 mmHg

Flash Point：

254.6±31.5 °C

Refractive Index：

1.608

Vapor Pressure：

4.99E-10mmHg at 25°C

Drug Information

MeSH：

Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)

MeSH Entry Terms：

1,3-bis(p-amidinophenoxy)propane

Propamidine Use and Manufacturing

as isethionate.A synthetic diamidine formulated as the isethionate or as dibromopropamidine isethionate for topical administration to the eye. Resistant clinical isolates of Acanthamoeba have been identified. It is available over the counter in eye drops.
Its activity against bacterial pathogens is poor, but it exhibits specific activity against Acanthamoeba spp. Reduction in sensitivity of Acanthamoeba during encystation might reflect changes in drug uptake. It is still recommende

Computed Properties

Molecular Weight:312.37
XLogP3:1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:312.15862589
Monoisotopic Mass:312.15862589
Topological Polar Surface Area:118
Heavy Atom Count:23
Complexity:350
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes