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Doxapram hydrochloride

Doxapram hydrochloride structure

CAS No:
113-07-5
Formula:
C24H30N2O2.ClH
Chemical Name:
Doxapram hydrochloride
Synonyms:
2-Pyrrolidinone,1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-,hydrochloride (1:1);2-Pyrrolidinone,1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-,monohydrochloride;2-Pyrrolidinone,1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-,monohydrochloride;2-Pyrrolidinone,1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-,hydrochloride;3,3-Diphenyl-1-ethyl-4-(2-morpholinoethyl)-2-pyrrolidinone hydrochloride;1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride;Stimulexin;Dopram;Doxapram hydrochloride;NSC 170958
Categories:
Chemical Reagents > Organic Reagents

Description

A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

Doxapram hydrochloride Basic Attributes

Molecular Weight：

414.96814

Exact Mass：

414.20700

EC Number：

204-022-3

NSC Number：

170958

DSSTox ID：

DTXSID9047837

HScode：

2934999090

Characteristics

PSA：

32.8

XLogP3：

3.85110

Boiling Point：

536.4ºC at 760mmHg

Flash Point：

278.2ºC

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

Stability/Shelf Life：

STABLE IN LIGHT & IN AIR /HYDROCHLORIDE/

Drug Information

MeSH：

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)|Drugs used for their effects on the respiratory system. (See all compounds classified as Respiratory System Agents.)

MeSH Entry Terms：

Docatone

Doxapram hydrochloride Use and Manufacturing

Uses

Anaesthetics

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:415.0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:414.2074059
Monoisotopic Mass:414.2074059
Topological Polar Surface Area:32.8
Heavy Atom Count:29
Complexity:487
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes