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Imipramine hydrochloride

Imipramine hydrochloride structure

CAS No:
113-52-0
Formula:
C19H24N2.ClH
Chemical Name:
Imipramine hydrochloride
Synonyms:
5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N,N-dimethyl-,hydrochloride (1:1);5H-Dibenz[b,f]azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-,monohydrochloride;5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N,N-dimethyl-,monohydrochloride;G 22355;5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride;N-(γ-Dimethylaminopropyl)iminodibenzyl hydrochloride;N-(3-Dimethylaminopropyl)iminodibenzyl hydrochloride;Imipramine hydrochloride;Tofranil;Imizine;Melipramine hydrochloride;Imizin;Imipramine monohydrochloride;Tofranile;Teperine;Feinalmin;Irmin;Novo-pramine;Timolet;Eupramin;Censtim;Censtin;Surplix;SK-Pramine;Imizinum;Pryleugan;Intalpram;Tipramine;Chrytemin;Apo-Imipramine;Praminil;Imidobenzyle;Iramil;Imidol;DIPD;Janimine;Imiprin;Impril;Imavate;Imilanyle;Efuranol;Promiben;Dimipressin;Deprinol;Presamine;Dyna-Zina;Depsol;Melipramin
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM in vitro.

Imipramine Hydrochloride is the hydrochloride salt form of imipramine, a synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04)|The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.

Imipramine hydrochloride Basic Attributes

Molecular Weight：

316.87

Exact Mass：

316.170624

EC Number：

204-030-7

UNII：

BKE5Q1J60U

NSC Number：

757074|114900

DSSTox ID：

DTXSID7040738

NCI Thesaurus Code：

C29116

Characteristics

PSA：

6.5

XLogP3：

4.74200

Appearance：

UN 1230 3/PG 2

Density：

1.041g/cm3

Melting Point：

174-175 °C

Boiling Point：

160 DEG C @ 0.1 MM HG

Flash Point：

179.7ºC

Water Solubility：

>47.5 [ug/mL]

Storage Conditions：

2-8ºC

Vapor Pressure：

6.6E-06mmHg at 25°C

Collision Cross Section：

165.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

UN 1230 3/PG 2

wgk germany：

hazard class code：

R23/25

safety instructions：

7-16-24-33-45-36-26

RTECS Number：

HO1925000

Marks：

Xn: Harmful;

Stability/Shelf Life：

Imipramine hydrochloride turns yellowish or reddish on exposure to light; slight discoloration does not affect potency, but marked discoloration is associated with loss of potency. Solutions of imipramine hydrochloride are stable at pH 4-5. During storage, minute crystals may form in the injection; the efficacy of the preparation is unaltered if the crystals are redissolved by immersing the ampul in hot water for 1 minute. /Imipramine hydrochloride/

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 92 companies from 4 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)|Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)

MeSH Entry Terms：

4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethyl-1-propanamine (1:2)

Imipramine hydrochloride Use and Manufacturing

Manufacturing Info：

5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride (1:1): INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:316.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:316.1706265
Monoisotopic Mass:316.1706265
Topological Polar Surface Area:6.5
Heavy Atom Count:22
Complexity:291
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a tricyclic antidepressant, and its main function is to block the reuptake of norepinephrine and 5-hydroxytryptamine by the central nervous system, thereby increasing the concentration of these two neurotransmitters in the synaptic cleft and exerting an antidepressant effect. This product also has anticholinergic, anti-α1 adrenergic receptor and anti-H1 histamine receptor effects, but has little effect on dopamine receptors.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Imipramine Hydrochloride Tablets
Ingredients	The main ingredient of this product is imipramine hydrochloride, and its chemical name is: N,N-dimethyl-10,11-dihydro-5H-dibenzo[b,f]azepine-5-propylamine hydrochloride.
Indication	1. When this product is used in combination with ethanol, it can enhance the inhibitory effect of the central nervous system. 2. When this product is used in combination with anticonvulsants, it can reduce the effect of anticonvulsants. 3. When this product is used in combination with antihistamines or anticholinergics, the efficacy of the drugs is mutually enhanced. 4. When this product is used in combination with estrogen or contraceptives containing estrogen, it can increase the adverse reactions of this product. 5. When this product is used in combination with adrenergic receptor agonists, it can cause severe hypertension and high fever. 6. When this product is used in combination with thyroid preparations, they can enhance each other's effects and cause arrhythmias. 7. When used in combination with monoamine oxidase, there is a risk of hypertension.
Specifications	25mg
Manufacturer	Chengdu Huayu Pharmaceutical Co., Ltd.

Imipramine Hydrochloride Tablets
Ingredients	The main ingredient of this product is imipramine hydrochloride, and its chemical name is: N,N-dimethyl-10,11-dihydro-5H-dibenzo[b,f]azepine-5-propylamine hydrochloride.
Indication	1. When this product is used in combination with ethanol, it can enhance the inhibitory effect of the central nervous system. 2. When this product is used in combination with anticonvulsants, it can reduce the effect of anticonvulsants. 3. When this product is used in combination with antihistamines or anticholinergics, the efficacy of the drugs is mutually enhanced. 4. When this product is used in combination with estrogen or contraceptives containing estrogen, it can increase the adverse reactions of this product. 5. When this product is used in combination with adrenergic receptor agonists, it can cause severe hypertension and high fever. 6. When this product is used in combination with thyroid preparations, they can enhance each other's effects and cause arrhythmias. 7. When used in combination with monoamine oxidase, there is a risk of hypertension.
Specifications	12.5mg
Manufacturer	Shanghai Sine Pharmaceutical Laboratories Co., Ltd.

Imipramine Hydrochloride Tablets
Ingredients	The main ingredient of this product is imipramine hydrochloride, and its chemical name is: N,N-dimethyl-10,11-dihydro-5H-dibenzo[b,f]azepine-5-propylamine hydrochloride.
Indication	1. When this product is used in combination with ethanol, it can enhance the inhibitory effect of the central nervous system. 2. When this product is used in combination with anticonvulsants, it can reduce the effect of anticonvulsants. 3. When this product is used in combination with antihistamines or anticholinergics, the efficacy of the drugs is mutually enhanced. 4. When this product is used in combination with estrogen or contraceptives containing estrogen, it can increase the adverse reactions of this product. 5. When this product is used in combination with adrenergic receptor agonists, it can cause severe hypertension and high fever. 6. When this product is used in combination with thyroid preparations, they can enhance each other's effects and cause arrhythmias. 7. When used in combination with monoamine oxidase, there is a risk of hypertension.
Specifications	25mg

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Registered Holders

R L Fine Chem Pvt.Ltd.

Japan
Active
LUPIN LTD

United Kingdom
Active
TAPI NL B.V.

France
Active

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Imipramine hydrochloride

CAS No.: 113-52-0

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