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Medrysone

Medrysone structure

CAS No:
2668-66-8
Formula:
C22H32O3
Chemical Name:
Medrysone
Synonyms:
Pregn-4-ene-3,20-dione,11-hydroxy-6-methyl-,(6α,11β)-;Pregn-4-ene-3,20-dione,11β-hydroxy-6α-methyl-;(6α,11β)-11-Hydroxy-6-methylpregn-4-ene-3,20-dione;U 8471;HMS;11β-Hydroxy-6α-methylpregn-4-ene-3,20-dione;6α-Methyl-Δ4-pregnene-11β-hydroxy-3,20-dione;Medrysone;11β-Hydroxy-6α-methylprogesterone;Hydroxymesterone;Medrifar;Visudrisone;Medrocort;Ophtocortin;Spectamedryn;NSC 63278;11β-Hydroxylmedroxyprogesterone
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Medrysone is a corticosteroid, in ophthalmology for the treatment of eye inflammations.

Solid

Medrysone is a corticosteroid hormone.|Medrysone is a corticosteroid used in ophthalmology.|Medrysone is a Corticosteroid. The mechanism of action of medrysone is as a Corticosteroid Hormone Receptor Agonist.|Medrysone is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions is accomplished.

Medrysone Basic Attributes

Molecular Weight：

344.48800

Exact Mass：

344.49

EC Number：

220-208-7

UNII：

D2UFC189XF

NSC Number：

63278

DSSTox ID：

DTXSID6045371

NCI Thesaurus Code：

C47598

ATC Code：

S - Sensory organs

Characteristics

PSA：

54.37000

XLogP3：

3.94030

Appearance：

Solid

Density：

1.13g/cm3

Melting Point：

156.5 °C

Boiling Point：

492.3ºC at 760mmHg

Flash Point：

265.7ºC

Refractive Index：

1.552

Water Solubility：

3.37e-02 g/L

Collision Cross Section：

183.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

TU5250000

Drug Information

Drug Indication：

For the treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, and epinephrine sensitivity.|FDA Label

Pharmacology：

Medrysone is a topical anti-inflammatory corticoidsteroids for ophthalmic use. In patients with increased intraocular pressure and in those susceptible to a rise in intraocular pressure, there is less effect on pressure with medrysone than with dexamethasone or betamethasone. Corticoidsteroids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation.

MeSH：

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

Absorption：

Rapidly absorbed following oral administration.

Mechanism of Action：

There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Initially, the drug binds to the glucocorticoid receptor in the cytosol. This migrates to the nucleus and binds to genetic elements which cause activation and repression of the involved genes in the inflammatory pathway.

MeSH Entry Terms：

11-hydroxy-6-methylprogesterone

Medrysone Use and Manufacturing

Uses

glucocorticoid

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Pharmaceuticals

Computed Properties

Molecular Weight:344.5
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:344.23514488
Monoisotopic Mass:344.23514488
Topological Polar Surface Area:54.4
Heavy Atom Count:25
Complexity:650
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes