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Cyclizine hydrochloride

Cyclizine hydrochloride structure

CAS No:
303-25-3
Formula:
C18H22N2.ClH
Chemical Name:
Cyclizine hydrochloride
Synonyms:
Piperazine,1-(diphenylmethyl)-4-methyl-,hydrochloride (1:1);Piperazine,1-(diphenylmethyl)-4-methyl-,monohydrochloride;N-Benzhydryl-N′-methylpiperazine monohydrochloride;Cyclizine hydrochloride;Marezine hydrochloride;Marzine;1-Benzhydryl-4-methylpiperazine hydrochloride
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Off-White Solid

Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.|A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)

Cyclizine hydrochloride Basic Attributes

Molecular Weight：

302.84200

Exact Mass：

302.15500

EC Number：

919-673-5

UNII：

W0O1NHP4WE

NSC Number：

169102

DSSTox ID：

DTXSID2047773

HScode：

2933599090

Characteristics

PSA：

6.48000

XLogP3：

3.70120

Density：

1.0551 (rough estimate)

Melting Point：

258-260 °C

Boiling Point：

363.7ºC at 760mmHg

Flash Point：

159.1ºC

Water Solubility：

FREELY SOL IN ETHER

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 3249

wgk germany：

safety instructions：

53-22-36/37/39-45

Marks：

Stability/Shelf Life：

SENSITIVE TO LIGHT /HYDROCHLORIDE/

Precautionary statement(s)：

Missing Phrase - N15.00950417-P260-P280-P302 + P352 + P312-P304 + P340 + P310-P403 + P233

Hazard Statements：

H301 + H311-H330-H361

Drug Information

MeSH：

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

MeSH Entry Terms：

Cyclizine

Cyclizine hydrochloride Use and Manufacturing

Antiemetic;H1 antagonist Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness. Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.

Computed Properties

Molecular Weight:302.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:302.1549764
Monoisotopic Mass:302.1549764
Topological Polar Surface Area:6.5
Heavy Atom Count:21
Complexity:253
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Related Drugs

Cyclizine Hydrochloride Capsules
Specifications	25mg
Manufacturer	Guangzhou Baiyunshan Pharmaceutical Co.,ltd.baiyunshan Hejigong Pharmaceutical Factory

Registered Holders

MICRO LABS LIMITED

European Union
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