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Dixyrazine

Dixyrazine structure

CAS No:
2470-73-7
Formula:
C24H33N3O2S
Chemical Name:
Dixyrazine
Synonyms:
Ethanol,2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]-;Ethanol,2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)-1-piperazinyl]ethoxy]-;2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]ethanol;UCB 3412;Dixyrazine;Esucos;10-[3-(4-Hydroxyethoxyethyl-1-piperazinyl)-2-methylpropyl]phenothiazine;[2-Methyl-3-(1-hydroxyethoxyethyl-4-piperazinyl)propyl]-10-phenothiazine;10-[2-Methyl-3-(4-hydroxyethoxyethyl-1-piperazinyl)propyl]phenothiazine;Esocalm;Metronal;Roscal;7326-88-7
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.

Dixyrazine is a member of phenothiazines.

Dixyrazine Basic Attributes

Molecular Weight：

427.60300

Exact Mass：

427.60

EC Number：

219-591-3

UNII：

7H368W3AYC

ATC Code：

N - Nervous system

HScode：

2934300000

Characteristics

PSA：

64.48000

XLogP3：

3.49270

Density：

1.166g/cm3

Melting Point：

192 °C

Boiling Point：

590ºC at 760mmHg

Flash Point：

310.6ºC

Refractive Index：

1.597

Collision Cross Section：

201 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)|Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

MeSH Entry Terms：

dixyrazine

Dixyrazine Use and Manufacturing

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:427.6
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:427.22934848
Monoisotopic Mass:427.22934848
Topological Polar Surface Area:64.5
Heavy Atom Count:30
Complexity:481
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes