4-Nitrosophenol

123.11

123.11

203-251-6

55EB58H2UP

239647|3124

3236

DTXSID0025991|DTXSID0075287

PALE YELLOW ORTHORHOMBIC NEEDLES, BROWNS @ 126 °C|CRYSTALLIZES IN LIGHT BROWN LEAFLETS

2908999090

49.7

1.27

P-benzoquinone monoxime is a black solid. (NTP, 1992)

1.3147 (rough estimate)

144 °C (decomp)

229.19°C (rough estimate)

114.6±22.6 °C

1.5423 (estimate)

H2O: <0.1 g/100 mL at 21 ºC;SOL IN HOT BENZENE

Keep away from sources of ignition. Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container. Flammables-area.

0.023mmHg at 25°C

Abdominal cavity-mouse LDL0: 250 mg/kg

Inflammable in case of open flame, high temperature, oxidant; burning produces toxic nitrogen oxide fumes

NITROSOPHENOL EXPLODES ON HEATING.

KA= 3.3X10-7 @ 25 °C

DECOMPOSES @ 144 °C

Insoluble in water.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Explosive

P-BENZOQUINONE MONOXIME explodes when heated. Explodes on contact with acid, alkali (NTP, 1992).

II

4.1

3236

21/22-40-41-68-51/53-22

15-24/25-26-61-49-47-36/37/39

SM4725000

Xn,N

The warehouse is ventilated, low temperature and dry; stored separately from oxidants, acids and alkalis

Explosive when mixed with oxidant

Stability Flammable. Incompatible with strong oxidizing agents. Explodes when heated, or in contact with acids or alkalies.

P201, P202, P264, P270, P273, P280, P281, P301+P312, P305+P351+P338, P308+P313, P310, P330, P391, P405, P501

H302

Literature sources indicate that this chemical is flammable. (NTP, 1992)

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P273, P280, P281, P301+P312, P305+P351+P338, P308+P313, P310, P330, P391, P405, and P501|H242 (48.72%): Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]|P201, P202, P210, P220, P234, P264, P270, P273, P280, P281, P301+P310, P301+P312, P305+P351+P338, P308+P313, P310, P321, P330, P370+P378, P391, P403+P235, P405, P411, P420, and P501|Aggregated GHS information provided by 78 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 150 [Substances (Self-Reactive / Temperature Controlled)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. LARGE SPILL: Consider initial evacuation for at least 250 meters (800 feet) in all directions. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should keep this material in a tightly-closed container under an inert atmosphere, and store it at refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

STORED BARRELS HEATED SPONTANEOUSLY & CAUSED A FIRE. CONTAMINATION OF THE BULK MATERIAL BY ACID OR ALKALI MAY CAUSE IGNITION. THE TENDENCY TO SPONTANEOUS IGNITION WAS FOUND TO BE ASSOCIATED WITH THE PRESENCE OF NITRATES IN SODIUM NITRITE USED IN PREPARATION.|DANGEROUS FIRE...RISK...

EXPLODES ON CONTACT WITH CONCN ACID, ALKALI, OR FIRE. A TECHNICAL GRADE EXPLODED ON STORAGE.|DANGEROUS...EXPLOSION RISK...MAY EXPLODE SPONTANEOUSLY.|NITROSOPHENOL EXPLODES ON HEATING...

highly toxic

PHENYLHYDROXYLAMINE IS DEGRADED IN AQUEOUS PHOSPHATE BUFFERS AT PHYSIOLOGICAL PH VALUES (6.8-7.4) TO GIVE NITROSOBENZENE, NITROBENZENE, & AZOXYBENZENE. THE REACTION IS OXYGEN-DEPENDENT & SUBJECT TO GENERAL ACID & GENERAL BASE CATALYSIS. AT PH OF APPROX 5.8 IN CACODYLATE BUFFER, IT IS CONVERTED TO P-NITROSOPHENOL IN ADDN TO NITROSOBENZENE, NITROBENZENE, & AZOXYBENZENE.|PARTIALLY PURIFIED, UNTREATED RAT LIVER CYTOSOL CONTAINS AT LEAST 2 ENZYMES WHICH RAPIDLY REDUCE THE C-NITROSO CARCINOGENS, P-NITROSO-N,N-DIMETHYLANILINE, P-NITROSOPHENOL, & 2-NITROSO-1-NAPHTHOL, IN THE PRESENCE OF NADPH OR NADH AT PH 6-7.

SYMPTOMS: This compound can cause skin irritation and sensitization. ACUTE/CHRONIC HAZARDS: This compound can cause skin irritation and sensitization. When exposed to heat or flame it burns explosively. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

CAN CAUSE SKIN IRRITATION, SENSITIZATION.

4-nitrosophenol

Phenol, 4-nitroso-: ACTIVE|SP - indicates a substance that is identified in a proposed Significant New Use Rule.

DETERMINATION OF 4-NITROSOPHENOL IN MEAT SMOKE BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY.