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Hexaethylene glycol

Hexaethylene glycol structure

Hexaethylene glycol 

structure
  • CAS No:

    2615-15-8

  • Formula:

    C12H26O7

  • Chemical Name:

    Hexaethylene glycol

  • Synonyms:

    3,6,9,12,15-Pentaoxaheptadecane-1,17-diol;Hexaethylene glycol;Hexaoxyethylene glycol;Ethanol,2,2′-[oxybis(oxy-2,1-ethanediyloxy-2,1-ethanediyloxy)]bis-;Hexagol;NSC 201209;2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Description

Hexaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].


Hexaethylene glycol is a poly(ethylene glycol).

Hexaethylene glycol Basic Attributes

282.333

282.33

220-045-1

201209

DTXSID2058629

2909499000

Characteristics

86.6

-1.9

viscous colourless liquid

1.0948 g/cm3 @ Temp: 60 °C

5-7 °C

217 °C

193.7±26.5 °C

1.460

0.000317mmHg at 25°C

Safety Information

NONH for all modes of transport

2

S23-S24/25

MM3670000

Stable. Incompatible with strong oxidizing agents.

P264, P280, P305+P351+P338, P33, P313

H319

|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 73 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

hexaethylene glycol

Hexaethylene glycol Use and Manufacturing

Uses

Substrate employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH)-TMEDA.1 Hexaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fl uids.

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern|Cosmetics -> Humectant; Solvent

Computed Properties

Molecular Weight:282.33
XLogP3:-1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:16
Exact Mass:282.16785316
Monoisotopic Mass:282.16785316
Topological Polar Surface Area:86.6
Heavy Atom Count:19
Complexity:141
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Hydrophilic agent and solubilizer, improves the solubility and stability of formulations; may enhance skin hydration and act as a penetration enhancer.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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