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2-Aminoethyl ether

2-Aminoethyl ether structure

2-Aminoethyl ether 

structure
  • CAS No:

    2752-17-2

  • Formula:

    C4H12N2O

  • Chemical Name:

    2-Aminoethyl ether

  • Synonyms:

    Ethanamine,2,2′-oxybis-;Ethylamine,2,2′-oxybis-;2,2′-Oxybis[ethanamine];Bis(2-aminoethyl) ether;1,5-Diamino-3-oxapentane;2-Aminoethyl ether;3-Oxa-1,5-diaminopentane;2,2′-Oxybis(ethylamine);2,2′-Oxydi[ethanamine];Jeffamine EDR 104;3-Oxa-1,5-pentanediamine;2-(2-Aminoethoxy)ethylamine;1,5-Diamine-3-oxapentane;2-(2-Aminoethoxy)ethanamine;EDR 104;2-(2-Aminoethoxy)ethan-1-amine

  • Categories:

    Organic Chemistry  >  Hydrazine or Hydroxylamine Derivatives

Description

22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].


Diamino-poly(ethylene glycol) is a poly(ethylene glycol) terminated with -NH2 groups. It is a poly(ethylene glycol) derivative and a primary amino compound.

2-Aminoethyl ether Basic Attributes

104.15

104.15

220-395-5

FFW1773ZZ6

DTXSID7041914

2922199090

Characteristics

61.3

-1.8

1.0±0.1 g/cm3

183-184 °C

74.8±14.1 °C

1.455

Safety Information

2735

8

45-36/37/39-26

C: Corrosive;

P260, P264, P273, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P391, P405, P501

H314

|Danger|H302 (70.71%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P363, P391, P405, and P501|Aggregated GHS information provided by 140 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Aminoethyl ether Use and Manufacturing

Methods of Manufacturing

A mixture of 15 (575 mg, 0.83 mmol) and 80percent hydrazine hydrate (8.3 mmol) was stirred under reflux for 4 h in CHCl

Ethanamine, 2,2'-oxybis-: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:104.15
XLogP3:-1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:104.094963011
Monoisotopic Mass:104.094963011
Topological Polar Surface Area:61.3
Heavy Atom Count:7
Complexity:28.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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