3-Pyridinesulfonamide

Under the protection of the Ar, 3 - pyridine sulfonyl chloride (1.457 g) is added in excess ammonia water (4.5 ml, ammonia content: 25 - 28percent), the temperature of the 40 °C reaction, 30 min after stopping the reaction, steaming and the removal of unreacted ammonia, adding 10 ml water precipitated yellow solid, filtering ethanol after heats crystallization (1.1 g, 85percent), Intermediate 78 : Pyridine-3-sulfonamide; To a solution of pyridine-3 -sulphonyl chloride (1 g, 5.6 mmol, 1 eq, commercially available from Davos) in THF (5 mL) is added ammonia in dioxane (23.9 mL, 2 M, 47.9 mmol, 8.5 eq). The resulting suspension is stirred at room temperature for 1 h. The solvent is removed and the residue is taken up in DCM. The organic phase is washed with a saturated aqueous solution of NHPyridine-3-sulfonyl chloride (1.00 g, 6.13 mmol, 1 eq) and ammonium carbonate (1.77 g, 18.4 mmol, 3 eq) were heated at 100 °C for 3 h. General procedure: Standard Procedure D for the Preparation of Sulfonamides (0054) A solution of sulfonyl chloride in methanol and ammonium hydroxide solution was stirred at 0° C. or room temperature. After the reaction was complete, methanol was removed under reduced pressure. The solution was extracted with ethyl acetate. The combined organic layers were dried over MgSOExample 79; N-(6-(2-(pyridine-5-sulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide; Step 1. Pyridine-3 -sulfonamide; Pyridine-3-sulfonyl chloride HCl (647.2 mg, 3.023 mmol) was suspended in DCM (9.0 mL) and NHEXAMPLE 4 STR109

Molecular Weight:158.18
XLogP3:-0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:158.01499861
Monoisotopic Mass:158.01499861
Topological Polar Surface Area:81.4
Heavy Atom Count:10
Complexity:194
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes