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S-Trityl-L-cysteine

S-Trityl-L-cysteine structure

CAS No:
2799-07-7
Formula:
C22H21NO2S
Chemical Name:
S-Trityl-L-cysteine
Synonyms:
3-(tritylthio)-l-alanin;3-tritylthio-l-alanine;s-(triphenylmethyl)-l-cystein;H-Cys(Trt)-OH (Cys of Animal Origin);H-Cys(Trt)-OH (Cys of Non Animal Origin);L-Cys(Trt)-OH;S-Trityl-L-cysteine≥ 98% (HPLC);H-CYS(TRT)-OH
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

almost white to light yellow granular powder

(2R)-2-amino-3-[(triphenylmethyl)thio]propanoic acid is a benzenoid aromatic compound.

S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth concentration (GI50) of 1.31 μM for a panel of 60 different tumor cell lines.

S-Trityl-L-cysteine Basic Attributes

Molecular Weight：

363.47

Exact Mass：

363.47

BRN：

2339626

EC Number：

218-195-8

Color/Form：

White or off-white

HScode：

29309090

Characteristics

PSA：

88.6

XLogP3：

Density：

1.1342 (rough estimate)

Melting Point：

182-183 °C (dec.)(lit.)

Boiling Point：

524.7±50.0 °C(Predicted)

Flash Point：

271.2±30.1 °C

Refractive Index：

111 ° (C=0.8, 0.04mol Ethanolic HCl)

Storage Conditions：

-20°C

Toxicity：

dog,LDLo,intravenous,150mg/kg (150mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. PB81-109993,

PKA：

2.22±0.10(Predicted)

Critical Temperature & Pressure：

Sealed in dry,Room Temperature

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-24/25

RTECS Number：

AY7710000

Marks：

Storage features：

Store at +4°C

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 47 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

3-tritylthio-L-alanine

S-Trityl-L-cysteine Use and Manufacturing

A protected cysteine for peptide synthesis.S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression.It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.

(+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.

Computed Properties

Molecular Weight:363.5
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:363.12930009
Monoisotopic Mass:363.12930009
Topological Polar Surface Area:88.6
Heavy Atom Count:26
Complexity:392
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of S-Trityl-L-cysteine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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S-Trityl-L-cysteine

CAS No.: 2799-07-7

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

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(+)-S-Trityl-L-cysteine 99% see COA kanbei

CAS No.: 2799-07-7

Grade: Industrial Grade

Content: 99%

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Guide of S-Trityl-L-cysteine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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S-Trityl-L-cysteine

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