N,N-Dimethyl-1H-benzimidazol-2-amine

Add 1 mmol of o-phenylenediamine to the reaction vessel.Add 0.05 mmol of cuprous iodide sequentially.1 mmol of sodium hydroxide, N, N-dimethylaminothioformyl chloride 2.5 mmol, 3 ml pyridine.Heated to 60 ° C at 120 W in a microwave reactorContinuous reaction for 10 min.After the reaction is completed, it is cooled to room temperature.Concentrated under reduced pressure, The product is purified by column chromatography.A white solid was obtained in 88percent yield.Add 1 mmol of o-phenylenediamine to the reaction vessel.Add 0.1 mmol of ferric chloride in sequence, Cesium carbonate 1 mmol, N, N-dimethylaminothioformyl chloride 2.5 mmol, 3 ml of tetrahydrofuran. Heat to 60 ° C for 5 h. After the reaction is completed, it is cooled to room temperature.Concentrated under reduced pressure, the product was purified by column chromatography.A white solid was obtained in a yield of 87percent.Commercially available 2-chloro-1H-benzo[d]imidazole (250 mg, 1.64 mmol) was dissolved in DMF (4.7 mL), dimethylamine (50percent aqueous solution, 0.50 mL, 4.92 mmol) was added, and the mixture was stirred with heating at 200°C for 30 min in an Emrys Optimizer microwave synthesizer. Water was added to the mixture, and the precipitated crystals were collected by suction filtration to give N, N-dimethyl-1H-benzo[d]imidazole-2-amine (234 mg, 89percent). ESIMS m/z: 162 (M + H)

Molecular Weight:161.20
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:161.095297364
Monoisotopic Mass:161.095297364
Topological Polar Surface Area:31.9
Heavy Atom Count:12
Complexity:158
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes