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Atropine methyl bromide

Atropine methyl bromide structure

CAS No:
2870-71-5
Formula:
C18H26NO3.Br
Chemical Name:
Atropine methyl bromide
Synonyms:
8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-,bromide (1:1),(3-endo)-;8-Methylatropinium bromide;1αH,5αH-Tropanium,3α-hydroxy-8-methyl-,bromide,(±)-tropate;8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-,bromide,endo-(±)-;8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-,bromide,(3-endo)-;Atropine methobromide;Hyoscyamine methyl bromide;Methylatropine bromide;Atropine methyl bromide;Methylatropinium bromide;N-Methylatropine bromide;Mintussin;Mydriasin;Tropin;N-Methylatropinium bromide;8-Azoniabicyclo[3.2.1]octane,3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-,bromide,endo-;NSC 61810
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine[1][2].

Atropine methyl bromide Basic Attributes

Molecular Weight：

384.31

Exact Mass：

383.11000

EC Number：

220-700-1

NSC Number：

61810

DSSTox ID：

DTXSID2045103

Characteristics

PSA：

46.53000

XLogP3：

-0.96170

Melting Point：

222-223 °C

Safety Information

Transport codes：

UN30779/PG3

hazard class code：

22-50/53

safety instructions：

36-60-61

RTECS Number：

YM3720000

Marks：

Xn,N

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

8-methylatropinium nitrate

Atropine methyl bromide Use and Manufacturing

Manufacturing Info：

8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, bromide (1:1), (3-endo)-: INACTIVE

Computed Properties

Molecular Weight:384.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:383.10961
Monoisotopic Mass:383.10961
Topological Polar Surface Area:46.5
Heavy Atom Count:23
Complexity:387
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

The bismuth carbonate in this product protects the gastric mucosa and has astringent and antidiarrheal effects. Heavy magnesium carbonate and sodium bicarbonate can neutralize gastric acid, reduce the ability of pepsin to digest gastric wall protein, and weaken or eliminate the corrosive and irritating effects of gastric acid on the surface of gastrointestinal ulcers. It has rapid spasmolysis, analgesia, and acid-reducing effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Acorus Calamus Bismuth Carbonate Tablets
Ingredients	This product is a compound preparation. Each tablet contains the main ingredients of 0.175g bismuth subcarbonate, 0.200g heavy magnesium carbonate, 0.1g sodium bicarbonate, 12.5mg calamus powder, 12.5mg rhubarb powder, and 0.25mg atropine bromide.
Indication	Not yet clear.
Specifications	Compound
Manufacturer	Sinopharm Medicine Holding Xingsha Pharmaceutical (Xiamen) Co., Ltd.

Compound Acorus Calamus Bismuth Carbonate Tablets
Ingredients	This product is a compound preparation. Each tablet contains the main ingredients of 0.175g bismuth subcarbonate, 0.200g heavy magnesium carbonate, 0.1g sodium bicarbonate, 12.5mg calamus powder, 12.5mg rhubarb powder, and 0.25mg atropine bromide.
Indication	Not yet clear.
Specifications	Compound
Manufacturer	Yusongyuan Pharmaceutical Co., Ltd.

Compound Acorus Calamus Basic Bismuth Nitrate Tablets
Ingredients	This product is a compound preparation. Each tablet contains the main ingredients of 0.175g bismuth subcarbonate, 0.200g heavy magnesium carbonate, 0.1g sodium bicarbonate, 12.5mg calamus powder, 12.5mg rhubarb powder, and 0.25mg atropine bromide.
Indication	Not yet clear.
Specifications	Compound
Manufacturer	Sinopharm Medicine Holding Xingsha Pharmaceutical (Xiamen) Co., Ltd.