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Home > Encyclopedia > 4-BROMO-3-HYDROXYBENZALDEHYDE

4-BROMO-3-HYDROXYBENZALDEHYDE

4-BROMO-3-HYDROXYBENZALDEHYDE structure

4-BROMO-3-HYDROXYBENZALDEHYDE 

structure
  • CAS No:

    20035-32-9

  • Formula:

    C7H5BrO2

  • Chemical Name:

    4-BROMO-3-HYDROXYBENZALDEHYDE

  • Synonyms:

    4-Bromo-3-hydroxybenzaldehyde;Benzaldehyde, 4-bromo-3-hydroxy-;4-Bromo-3-hydroxy-benzaldehyde;PubChem16848;ACMC-209f5d;3-Hydroxy-4-bromobenzaldehyde;SCHEMBL6841897;CTK8B1131;KS-00000PSV;DTXSID10563671

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

4-BROMO-3-HYDROXYBENZALDEHYDE Basic Attributes

201.019

199.94700

DTXSID10563671

2913000090

Characteristics

37.3

2

White solid

1.737 g/cm3

132ºC

265°C at 760 mmHg

114.087ºC

4-BROMO-3-HYDROXYBENZALDEHYDE Use and Manufacturing

Reaction step: 35.4 g of 3-hydroxybenzaldehyde and 212 ml of dichloromethane were added to a clean reaction vessel, and the mixture was replaced with vacuum nitrogen three times, stirred and cooled to below 0 ° C, 35.4 g of liquid bromine was added dropwise, and 250 ml of water was added after completion of the reaction. Adjust the pH to neutral with liquid alkali, filter by cooling, add 354ml of wet product toluene to dissolve, separate the water layer, warm the organic phase to reflux, filter by temperature, and dry to obtain 4-bromo-3-hydroxy-benzaldehyde 35.5. g.

Computed Properties

Molecular Weight:201.02
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:199.94729
Monoisotopic Mass:199.94729
Topological Polar Surface Area:37.3
Heavy Atom Count:10
Complexity:127
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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