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Dexamethasone phosphate

Dexamethasone phosphate structure

CAS No:
312-93-6
Formula:
C22H30FO8P
Chemical Name:
Dexamethasone phosphate
Synonyms:
Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-,(11β,16α)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11β,17,21-trihydroxy-16α-methyl-,21-(dihydrogen phosphate);Pregna-1,4-diene-3,20-dione,9-fluoro-11β,17,21-trihydroxy-16α-methyl-,21-phosphate;(11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione;Dexamethasone 21-phosphate;Betnelan phosphate;Dexamethasone phosphate;Dexamethasone 21-dihydrogen phosphate;Wymesone;Dexamethasone orthophosphate;Micromethason;2588541-25-5
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

ChEBI: A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.

Dexamethasone phosphate is a steroid phosphate that is the 21-O-phospho derivative of dexamethasone. It has a role as a glucocorticoid receptor agonist. It is a steroid phosphate, an 11beta-hydroxy steroid, a 17-hydroxy steroid, a 3-oxo-Delta(4) steroid, a fluorinated steroid and a tertiary alpha-hydroxy ketone. It derives from a dexamethasone. It is a conjugate acid of a dexamethasone phosphate(2-).

Dexamethasone phosphate Basic Attributes

Molecular Weight：

472.4409642

Exact Mass：

472.44

EC Number：

206-232-0

UNII：

2BP70L44PR

DSSTox ID：

DTXSID2047430

HScode：

2937290090

Characteristics

PSA：

151.17000

XLogP3：

2.01270

Density：

1.45g/cm3

Boiling Point：

669.6ºC at 760mmHg

Flash Point：

358.7ºC

Refractive Index：

1.594

Toxicity：

Oral-Mouse LD: >1000 mg/kg

Flammability characteristics：

Flammable; burning produces toxic phosphorus oxide and fluoride fumes

Safety Information

hazard class code：

Marks：

Storage features：

Ventilated, low temperature and dry

Precautionary statement(s)：

P201, P202, P260, P264, P270, P281, P308+P313, P314, P405, P501

Hazard Statements：

H361

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

MeSH Entry Terms：

Decadron phosphate

Dexamethasone phosphate Use and Manufacturing

Uses

A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.

Use Classification：

Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:472.4
XLogP3:0.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:472.16623307
Monoisotopic Mass:472.16623307
Topological Polar Surface Area:141
Heavy Atom Count:32
Complexity:973
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Dexamethasone sodium phosphate

CAS No.: 312-93-6

Content: 99.00%

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