2,3,6-Trichlorobenzoic acid

225.46

225.46

200-026-4

VI4ST7ZIQG

53133

2769

DTXSID6040296

2916399090

37.3

2.71 (est)

1.635g/cm3

124.5 °C

324.5ºC at 760mmHg

150.1ºC

1.611

In water, 7.7X10+3 mg/L at 22 deg C

-20°C

5.5X10-4 mm Hg at 25 deg C

Oral-Rat LD50: 650 mg/kg

Combustion produces toxic chloride gas

Henry's Law constant = 2.12X10-8 atm-cu m/mol at 25 °C (est)

pKa = 1.84 (est)

Hydroxyl radical reaction rate constant = 1.43X10-13 cu cm/molec sec at 25 °C (est)

UN28116.1/PG1

2

22-51/53

61

DH7700000

Xn,N

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

P264, P270, P273, P301+P312, P330, P391, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|H302 (99.25%): Harmful if swallowed [Warning Acute toxicity, oral]|Aggregated GHS information provided by 134 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P264, P270, P301+P312, P330, and P501

For several good reasons, .... herbicides ... should be handled and applied only with full attention to safety measures that minimize personal contact. Many formulations contain adjuvants (stabilizers, penetrants, surfactants) that may have significant irritating and toxic effects. A number of premixed formulations contain two or more active ingredients; the companion pesticides may be more toxic than the principal herbicide. Good hygienic practice should not be disregarded just because a pesticide is reported to have a high LD50 in laboratory rodents.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

moderately toxic

LD50 Rat oral 1500 mg/kg|LD50 Rat oral 650 mg/kg|LD50 Rat ip 1000 mg/kg|LD50 Mouse oral 615 mg/kg|For more Non-Human Toxicity Values (Complete) data for 2,3,6-TRICHLOROBENZOIC ACID (8 total), please visit the HSDB record page.

2,3,6-Trichlorobenzoic acid's production may result in its release to the environment through various waste streams; its former use in herbicide formulations(1) will have resulted in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 65(SRC), determined from a structure estimation method(2), indicates that 2,3,6-trichlorobenzoic acid is expected to have high mobility in soil(SRC). The estimated pKa of 2,3,6-trichlorobenzoic acid is 1.8(3), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). 2,3,6-Trichlorobenzoic acid had high mobility based upon observations from laboratory and field studies that indicate that the 2,3,6-trichlorobenzoic acid readily leaches through soil(5-7). Volatilization from moist soil surfaces is not expected to be an important fate process because anions do not volatilize. 2,3,6-Trichlorobenzoic acid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.5X10-4 mm Hg(5). Screening studies have shown 2,3,6-trichlorobenzoic acid to be resistant to biodegradation; 2,3,6-trichlorobenzoic acid, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(8).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 65(SRC), determined from a structure estimation method(2), indicates that 2,3,6-trichlorobenzoic acid is expected to adsorb to suspended solids and sediment(SRC). An estimated pKa of 1.8(3) indicates 2,3,6-trichlorobenzoic acid will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(4). According to a classification scheme(5), BCFs of <3.5 in carp (Cypinus carpio), exposed over a 6-week period(6) suggest bioconcentration in aquatic organisms is low(SRC). 2,3,6-Trichlorobenzoic acid reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test(6), suggesting that biodegradation is not an important environmental fate process in water(SRC). In an anaerobic freshwater lake sediment grab sample study, 100% of the 2,3,6-trichlorobenzoic acid added to the sediment was transformed in 84-364 days to 2,6-dichlorobenzoate without evidence of mineralization(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,3,6-trichlorobenzoic acid, which has a vapor pressure of 5.5X10-4 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2,3,6-trichlorobenzoic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 112 days(SRC), calculated from its rate constant of 1.43X10-13 cu cm/molecule-sec at 25 °C(3). Particulate-phase 2,3,6-trichlorobenzoic acid may be removed from the air by wet or dry deposition(SRC). The photodegradation of 2,3,6-trichlorobenzoic acid observed in water solutions irradiated at wavelengths >290 nm in laboratory tests(4) suggests that the 2,3,6-trichlorobenzoic acid may be susceptible to direct photolysis in the ambient atmosphere(SRC).

The rate constant for the vapor-phase reaction of 2,3,6-trichlorobenzoic acid with photochemically-produced hydroxyl radicals is 1.43X10-13 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 112 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2,3,6-Trichlorobenzoic acid is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Water solutions of 2,3,6-trichlorobenzoic acid were irradiated at wavelengths >290 nm for a 10 min period; this greatly reduced the phytotoxicity of the 2,3,6-trichlorobenzoic acid, although it is difficult to relate this laboratory data utilizing artificial light to environmental photolysis rates in sunlight(3).

3.47|The BCF of 2,3,6-trichlorobenzoic acid was <0.4 at a concentration of 293 ppb and <3.5 at a concentration of 29.3 ppb using carp (Cypinus carpio) which were exposed over a 6-week period(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2,3,6-trichlorobenzoic acid can be estimated to be 65(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2,3,6-trichlorobenzoic acid is expected to have high mobility in soil(SRC). The estimated pKa of 2,3,6-trichlorobenzoic acid is 1.8(3), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). 2,3,6-Trichlorobenzoic acid readily leaches through soil; 2,3,6-trichlorobenzoic acid has been found at depths of 11 feet following surface application(5). Approximately 10% of the 2,3,6-trichlorobenzoic acid applied at rates of 0.2 and 0.6 kg/hectare to 8 experimental plots leached an unspecified distance to the tile-drain groundwater in 3 months(6). 2,3,6-Trichlorobenzoic acid was found to be readily leached from soil columns containing 4 different types of soil (Staten Island peaty muck, Stockton adobe clay, Yolo fine sandy loam and Hesperia sandy loam)(7). In a soil column filled with silty clay loam, 2,3,6-trichlorobenzoic acid was leached 20 inches upon the addition of sufficient water to wet the column to 22 inches(8). Most of the residual herbicidal activity of 2,3,6-trichlorobenzoic acid applied to a test field at a rate of 15-30 lb/acre was present in the second, third and fourth foot depth of the 6 foot of depth tested(9).

An estimated pKa of 1.8(1) indicates 2,3,6-trichlorobenzoic acid will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces or moist soil is not expected to be an important fate process(2). 2,3,6-Trichlorobenzoic acid is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 5.5X10-4 mm Hg(3).

GROUNDWATER: 2,3,6-Trichlorobenzoic acid has been found in groundwater (tile-drain water from an unspecified depth) in Malmohus, Sweden, under fields treated with the 2,3,6-trichlorobenzoic acid 3 months previously(1). The concn found in 31 samples averaged 12.5 ppb and ranged up to 70 ppb(1).|SURFACE WATER: 2,3,6-Trichlorobenzoic acid was found in 70% of samples taken in 10 wetlands after torrential rain storms (390-465 mm of rain from May 20 to July 3, 2000) in Neville, Canada(1). 2,3,6-Trichlorobenzoic acid was not found one year later following drought conditions (62 mm of rain May 20 to July 5, 2001) from samples taken in 5 of the previously sampled wetlands(1).|RAIN/SNOW/FOG: Rain water samples were taken during torrential rain storm events (390-465 mm of rain from May 20 to July 3, 2000) in Neville, Canada. 2,3,6-Trichlorobenzoic acid was tested for as one of the herbicides applied within the area subjected to the storm (1,700 sq km) but not detected in the rain sample analyzed on July 3, 2000(1).

2,3,6-Trichlorobenzoic acid was detected in 2 of 216 composite samples of 82 cooked and uncooked common foods collected from 18 markets in 3 different geographical areas of the U.S. (Boston, MA, Kansas City, MO and Los Angeles, CA) between June 1964 and April 1965(1). The concn found in one of the positive samples was 0.02 ppm and in the other the concn was below an unspecified quantitative sensitivity limit(1). The only composite category listed as containing 2,3,6-trichlorobenzoic acid is the oils, fats and shortening composite(1). 2,3,6-Trichlorobenzoic acid was not detected in more than 28,000 U.S. domestic samples and 18,000 imported samples of foods other than fluid milk collected between fiscal year 1970 and 1976 in the FDA Total Diet Program(2).

ENVIRONMENTAL: 2,3,6-Trichlorobenzoic acid was detected not quantified in 3 samples of U.S. domestic fluid milk out of 4,638 total samples collected and tested between fiscal years 1970 and 1976 in the FDA Total Diet Program(1). All of the positive samples were collected in 1971(1).

Occupational exposure to 2,3,6-trichlorobenzoic acid may occur through inhalation and dermal contact with this compound at workplaces where 2,3,6-trichlorobenzoic acid is produced or used. Monitoring data indicate that limited general population exposure to 2,3,6-trichlorobenzoic acid may have occurred via ingestion of contaminated food and dermal contact with contaminated water following flood events in areas where this herbicide was used. (SRC)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

2,3,6-TBA

(1966) 2.967X10+6 lbs AI/yr

Benzac|Fen-all|Benzabar|Tryben|For more Formulations/Preparations (Complete) data for 2,3,6-TRICHLOROBENZOIC ACID (7 total), please visit the HSDB record page.

Benzoic acid, 2,3,6-trichloro-: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Determination of acid and hydroxybenzonitrile herbicide residues in soil by gas-liquid chromotography after ion pair alkylation. Recoveries greater than 80% were achieved. The detection limits were 0.01-0.05 ug/g.|Product and salt analysis by titration or by glc... In mixture with MCPA, by titration or by glc of a derivative... Residues determined by glc of a suitable derivative...

Agrochemicals -> Herbicides|HERBICIDES